Evidence map›Paper›PMID 30630899›Full record

ReviewScience (New York, N.Y.)2019

An evolutionary perspective on immunometabolism.

Andrew Wang, Harding H Luan, Ruslan Medzhitov

Registry-linked trialAbstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04267809 (Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection), which is not on this map. Cited by 201 papers.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04267809 phase2completednot on this mapstarted 2021, after this paper: background citation

Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection

TypeinterventionalSponsorSingapore General HospitalRan2021 to 2023Enrolled32ConditionsEndoplasmic Reticulum Stress, Viral Infection, Yellow FeverArmsMetformin Hydrochloride, Calcium and Vitamin D
3 · Its place in the literature

Who cites it

201 citing papers in PubMed.

  1. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
    Review
  2. Article
  3. Review
  4. Review
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  6. Review
  7. Review
  8. Review
  9. Article
  10. Parsing Neurometabolic Signatures of Multiple Sclerosis with MRSI and cPCA.medRxiv : the preprint server for health sciences · 2026
    Article
  11. Sepsis and the immunometabolic inflammatory response.npj metabolic health and disease · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  20. Article

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew WangDepartment of Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-6951-8081
Harding H LuanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-2044-2159
Ruslan MedzhitovDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. ruslan.medzhitov@yale.edu.ORCID 0000-0002-7021-2012

Funding

INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
Regulation of Metabolic Programs for Host Tolerance to InflammationK08AI128745 · NIAID · YALE UNIVERSITY · PI WANG, ANDREW · 2017 to 2021
$784k
NIAID NIH HHS K08 AI128745NIAID NIH HHS T32 AI007019
6 · The paper itself

Abstract

Metabolism is at the core of all biological functions. Anabolic metabolism uses building blocks that are either derived from nutrients or synthesized de novo to produce the biological infrastructure, whereas catabolic metabolism generates energy to fuel all biological processes. Distinct metabolic programs are required to support different biological functions. Thus, recent studies have revealed how signals regulating cell quiescence, proliferation, and differentiation also induce the appropriate metabolic programs. In particular, a wealth of new studies in the field of immunometabolism has unveiled many examples of the connection among metabolism, cell fate decisions, and organismal physiology. We discuss these findings under a unifying framework derived from the evolutionary and ecological principles of life history theory.

Indexed as

Cell DifferentiationCell ProliferationEnergy MetabolismAnimalsBiological EvolutionHumansHypothalamusImmune SystemImmune Tolerance

Identifiers

PMID30630899
PMCPMC6892590

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.