ArticleJournal of molecular histology2019
Osteogenic and angiogenic characterization of mandible and femur osteoblasts.
Article in Journal of molecular histology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The influence of hypoxia on tissue regeneration in oral and maxillofacial surgery - a systematic review.Clinical oral investigations · 2026Pooled it
- Unraveling Jawbone Susceptibility: Distinctive Features Underlying Medication-Related Osteonecrosis.Dentistry journal · 2026Review
- Tissue origin dictates functional diversity of BMSC-derived EVs in bone regeneration.Frontiers in cell and developmental biology · 2025Article
- 3D-Cultured MC3T3-E1-Derived Exosomes Promote Endothelial Cell Biological Function under the Effect of LIPUS.Biomolecules · 2024Article
- Site-specific periosteal cells with distinct osteogenic and angiogenic characteristics.Clinical oral investigations · 2023Article
- Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis.Journal of translational medicine · 2023Article
- Uncovering the unique characteristics of the mandible to improve clinical approaches to mandibular regeneration.Frontiers in physiology · 2023Review
- Distinct osteogenic effect of different periosteum derived cells via Hippo-YAP cascade signaling.Cell cycle (Georgetown, Tex.) · 2023Article
- Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs.Biomaterials research · 2022Article
- Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold.Regenerative biomaterials · 2021Article
- Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials.Advanced healthcare materials · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few studies have compared the osteogenic ability of osteoblasts from craniofacial and long bones, and the results are contradictory. Additionally, the angiogenic characteristics of osteoblasts from these different bones remain unknown. We obtained osteoblasts from the rat mandible (MOBs) and femur (FOBs) to investigate their proliferative capacity and osteogenic potential, and using a co-culture system with human umbilical vein endothelial cells (HUVECs), we explored their angiogenic capabilities in vitro. FOBs exhibited higher alkaline phosphatase activity and increased matrix mineralization and expressed more osteogenic related marker genes, while MOBs proliferated at the highest rate and showed elevated expression of angiogenesis-related factors. Conditioned media from MOBs enhanced the expression of angiogenesis-related factors in HUVECs. Furthermore, the conditioned media generated from MOBs showed stronger promotion of proliferation, migration, and tube-like structure formation in HUVECs, suggesting that MOBs had a stronger pro-angiogenic effect on HUVECs than FOBs. Taken together, these results indicate that osteoblasts possess skeletal site-specific differences in osteogenic and angiogenic capabilities, and this might lead to a better understanding of the molecular impact of bone cells from different bone entities on maxillofacial bone reconstructions.
Indexed as
Identifiers
30635760What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.