ArticleJournal of cellular physiology2019
Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.
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Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Atrial TRPM2 Channel-Mediated CaCells · 2025Article
- TRPM2: a pivotal player in tumor progression and a promising therapeutic target.Cancer cell international · 2025Review
- Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis.Life science alliance · 2024Article
- Bidirectional regulation mechanism of TRPM2 channel: role in oxidative stress, inflammation and ischemia-reperfusion injury.Frontiers in immunology · 2024Review
- Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis.International journal of molecular sciences · 2022Review
- Article
- Role of the LRP1-pPyk2-MMP9 pathway in hyperoxia-induced lung injury in neonatal rats.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase.International journal of molecular sciences · 2021Article
- The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases.Frontiers in synaptic neuroscience · 2021Review
- TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions.Redox biology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Barbara A MillerDepartment of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
JuFang WangCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Jianliang SongCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Xue-Qian ZhangCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Iwona Hirschler-LaszkiewiczDepartment of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Santhanam ShanmughapriyaCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Dhanendra TomarCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Sudasan RajanCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Arthur M FeldmanDepartment of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0001-8351-9569
Muniswamy MadeshCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Shey-Shing SheuCenter for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Joseph Y CheungCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0002-8024-9177
Temple University · USPennsylvania State University · USThe University of Texas Health Science Center at San Antonio · USThomas Jefferson University · US
Funding
Targeted Cancer Therapeutics and Heart Failure: Mechanisms and Post-injury RepairP01HL091799 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI HOUSER, STEVEN R · 2008 to 2018
$23.1MCa2+ and ROS Crosstalk Signaling in Cardiac MitochondriaR01HL093671 · NHLBI · UNIVERSITY OF ROCHESTER · PI SHEU, SHEY-SHING · 2010 to 2023
$5.1MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MMitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0MInvolvement of BAG3 in HIV-1 induced cardiomyopathyR01HL123093 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y, FELDMAN, ARTHUR M · 2014 to 2018
$3.7MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MSIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETINR01DK046778 · NIDDK · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI MILLER, BARBARA A. · 1994 to 2011
$2.6MDynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5MMethylene blue as an antidote against hydrogen sulfide intoxicationU01NS097162 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAOUZI, PHILIPPE A · 2016 to 2018
$2.2MTrpm2: A novel target in Onco-cardiologyR01HL137426 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y · 2017 to 2020
$2.2MInhibition of MCUR1-MCU mediated mitochondrial Ca2+ uptake prevents I/R injuryR01HL119306 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2014 to 2017
$1.6MTRPM2, Mitochondria, and Cell SurvivalR01GM117014 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MILLER, BARBARA A. · 2016 to 2019
$1.2MNational Heart, Lung, and Blood Institute PO1-HL91799National Heart, Lung, and Blood Institute RO1-HL093671National Heart, Lung, and Blood Institute RO1-HL122124National Heart, Lung, and Blood Institute RO1-HL123093National Heart, Lung, and Blood Institute RO1-HL137266National Heart, Lung, and Blood Institute RO1-HL137426National Heart, Lung, and Blood Institute RO1-HL86699National Institute of Diabetes and Digestive and Kidney Diseases RO1-DK46778National Institute of General Medical Sciences R01-GM117014National Institute of Neurological Disorders and Stroke R21-NS098991National Institute of Neurological Disorders and Stroke UO1-NS097162NHLBI NIH HHS P01 HL091799NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL093671NHLBI NIH HHS R01 HL119306NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL123093NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R01 HL137426NIDDK NIH HHS R01 DK046778NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM117014NINDS NIH HHS R21 NS098991NINDS NIH HHS U01 NS097162
Abstract
The mechanisms by which Trpm2 channels enhance mitochondrial bioenergetics and protect against oxidative stress-induced cardiac injury remain unclear. Here, the role of proline-rich tyrosine kinase 2 (Pyk2) in Trpm2 signaling is explored. Activation of Trpm2 in adult myocytes with H
Indexed as
hypoxia-reoxygenationischemic cardiomyopathymitochondrial oxidantsoxidative injuryvoltage-independent Ca2+ channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.