SynthesisJournal of clinical hypertension (Greenwich, Conn.)2019
Cardiovascular outcomes in patients with diabetes when initiating blood pressure lowering at baseline SBP between 130 and 140 mm Hg: A meta-analysis.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular outcomes in patients with diabetes when initiating blood pressure lowering at baseline SBP between 130 and 140 mm Hg: A meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Update of the clinical guideline for hypertension diagnosis and treatment in Iran.Clinical hypertension · 2024Article
- Cardiovascular events with blood pressure lowering in patients with diabetes and systolic blood pressure below 140 mm Hg.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Response to: Cardiovascular events with blood pressure lowering in patients with diabetes and systolic blood pressure below 140 mm Hg.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficacy and safety of blood pressure (BP) lowering initiated at baseline systolic BP (SBP) of 130-140 mm Hg in patients with diabetes remain controversial. The authors aimed to investigate the benefits and harms of BP lowering initiated at these levels for patients with diabetes. Medline and EMBASE were searched from inception to March 10, 2018. The primary outcome was major cardiovascular events. Random-effects model was used to pool all the estimates. Six trials with 21 574 diabetics were included. In diabetics, initiating BP lowering at baseline SBP of 130 and 140 mm Hg did not reduce the rate of major cardiovascular events (RR, 1.01 [95% CI, 0.93-1.10]), finding that was consistent in subgroup and sensitivity analyses. Moreover, BP lowering did not reduce the risks of myocardial infarction (RR, 0.99 [95% CI, 0.85-1.16]), stroke (0.83 [95% CI, 0.54-1.27]), heart failure (0.91 [95% CI, 0.79-1.04]), albuminuria (0.93 [95% CI, 0.84-1.04]), end-stage renal disease (0.93 [95% CI, 0.70-1.24]), cardiovascular death (1.25 [95% CI, 0.90-1.74]) and all-cause death (1.05 [95% CI, 0.94-1.17]) in patients with diabetes and baseline SBP of 130-140 mm Hg but possibly increase the risks of serious adverse events (RR, 2.00 [95% CI, 1.33-3.01]) and hypotension (5.30 [95% CI, 0.99-28.40]). In diabetics, initiating BP lowering at baseline SBP of 130-140 mm Hg may not produce any benefit but probably increase the risks of serious adverse events and hypotension. It may not be recommended to initiate BP lowering at a threshold of SBP lower than 140 mm Hg for diabetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.