Evidence map›Paper›PMID 30638954›Full record

ReviewTrends in parasitology2019

Kinetoplast Division Factors in a Trypanosome.

Kojo Mensa-Wilmot, Benjamin Hoffman, Justin Wiedeman, Catherine Sullenberger, Amrita Sharma

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Steroidal Antimetabolites Protect Mice againstMolecules (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kojo Mensa-WilmotDepartment of Cellular Biology, 724 Biological Sciences Building, University of Georgia, Athens, Georgia 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA. Electronic address: mensawil@uga.edu.
Benjamin HoffmanDepartment of Cellular Biology, 724 Biological Sciences Building, University of Georgia, Athens, Georgia 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA.
Justin WiedemanDepartment of Cellular Biology, 724 Biological Sciences Building, University of Georgia, Athens, Georgia 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA.
Catherine SullenbergerDepartment of Cellular Biology, 724 Biological Sciences Building, University of Georgia, Athens, Georgia 30602, USA.
Amrita SharmaDepartment of Cellular Biology, 724 Biological Sciences Building, University of Georgia, Athens, Georgia 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA.
University of Georgia · US

Funding

Optimization and Modes of Action of NEU-4438, a New Anti-trypanosome Lead DrugR01AI124046 · NIAID · NORTHEASTERN UNIVERSITY · PI FERRINS, LORI, MENSA-WILMOT, KOJO A. · 2016 to 2025
$6.0M
Curaxin-137, A New Lead for Anti-Trypanosome Drug Discovery - Resubmission - 1R01AI126311 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L, POLLASTRI, MICHAEL P · 2017 to 2020
$2.7M
NIAID NIH HHS R01 AI124046NIAID NIH HHS R01 AI126311
6 · The paper itself

Abstract

Inheritance of the single mitochondrial nucleoid (kinetoplast) in the trypanosome requires numerous proteins, many of whose precise roles are unclear. By considering kinetoplast DNA (kDNA) as a template for cleavage into two equal-size networks, we predicted sets of mutant kinetoplasts associated with defects in each of the five steps in the kinetoplast cycle. Comparison of these kinetoplasts with those obtained after gene knockdowns enabled assignment of proteins to five classes - kDNA synthesis, site of scission selection, scission, separation, and partitioning. These studies highlight how analysis of mutant kinetoplast phenotypes may be used to predict functional categories of proteins involved in the biogenesis of kinetoplasts.

Indexed as

DNA, KinetoplastMutationProtozoan ProteinsTerminology as TopicTrypanosomaDNA, KinetoplastProtozoan ProteinskDNAkinetoplastmitochondrial DNAsegregationTrypanosoma bruceitrypanosome

Identifiers

PMID30638954
PMCPMC6368890
OpenAlexW2910755776

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.