Evidence map›Paper›PMID 30644770›Full record

SynthesisCurrent eye research2019

Interleukin-6 and Diabetic Retinopathy: A Systematic Review and Meta-Analysis.

Yang Yao, Rong Li, Junhui Du, Lihui Long, Xiangnan Li, Na Luo

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current eye research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05310916 phase3unknown statusstarted 2022, after this paper: background citation

Evaluation of the Effect of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors on Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus

Ran2022Enrolled60Registered outcomes3Posted comparisons0ConditionsDiabetic RetinopathyArmsDapagliflozin 10mg Tab plus another oral hypoglycemic agent, Two oral hypoglycemic agents other than dapagliflozin
PMID 31019585PMID 26078479PMID 27159554PMID 28231831PMID 29219149PMID 31491943PMID 33274239PMID 33634250other papers from this trial
Open the trial in the graph
NCT04940338 phase4completednot on this mapstarted 2021, after this paper: background citation

The Effect of Topical Corticosteroids and Topical NSAIDs Perioperatively on IL6 Levels in Aqueous Humor and on Incidence of PCME in Patients With NPDR

TypeinterventionalSponsorKlinički Bolnički Centar ZagrebRan2021 to 2022Enrolled90ConditionsCystoid Macular Edema Following Cataract SurgeryArmsBromfenac Ophthalmic 0.09% Ophthalmic Solution, Dexamethasone Ophthalmic, Placebo, Phacoemulsification surgery (PHACO)
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. Gout and diabetic retinopathy: elevated risks and the protective role of urate-lowering therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang Yaoa Department of Central Laboratory, The First Affiliated Hospital , Xi'an Medical University , Xi'an , Shaanxi , China.
Rong Lib Department of Ophthalmology, The First Affiliated Hospital , Xi'an Medical University , Xi'an , Shaanxi , PR China.
Junhui Duc Department of Ophthalmology, Xi'an Ninth Hospital , Medical College of Xi'an Jiaotong University , Xi'an , Shanxi , China.
Lihui Longd Department of pharmacy, The First Affiliated Hospital , Xi'an Medical University , Xi'an , Shaanxi , PR China.
Xiangnan Lie Clinical Medicine (Four-year program) of Grade 2014 , Xi'an Medical University , Xi'an , Shaanxi , PR China.
Na Luoe Clinical Medicine (Four-year program) of Grade 2014 , Xi'an Medical University , Xi'an , Shaanxi , PR China.
Xi'an Medical University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterleukin-6 (IL-6) is produced by a variety of cells involved in inflammation and acts as local intensification signals in pathological processes associated with chronic eye inflammation. This meta-analysis was performed to provide a better understanding of the relationship between IL-6 and diabetic retinopathy.

methodsThe study was started with systematic search for literatures by using the PubMed, Web of Science and Embase online databases. The standard mean difference (SMD) and its 95% confidence intervals (CIs) were was included and then pooled with a random effects model.

resultsThirty-one articles, containing1099 DR patients and 1010 controls, were included in this meta-analysis. The level of IL-6 in the DR group was found to be higher than that in the control group (SMD: 2.12, 95% CI: 1.53-2.70, p < 0.00001).Obvious heterogeneity existed between the studies (p < 0.00001, I

Indexed as

Diabetic RetinopathyHumansInterleukin-6IL6 protein, humanInterleukin-6diabetic retinopathyInterleukin-6meta-analysis

Identifiers

PMID30644770
OpenAlexW2909580825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.