ArticlePLoS genetics2019
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Cell-Mediated Branch Fusion in the Drosophila Trachea.Results and problems in cell differentiation · 2024Review
- Article
- The impact of cell size on morphogen gradient precision.Development (Cambridge, England) · 2023Article
- Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues.Nature communications · 2021Article
- Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism.The EMBO journal · 2020Article
- Drosophila PTPMT1 Has a Function in Tracheal Air Filling.iScience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most organs of multicellular organisms are built from epithelial tubes. To exert their functions, tubes rely on apico-basal polarity, on junctions, which form a barrier to separate the inside from the outside, and on a proper lumen, required for gas or liquid transport. Here we identify apnoia (apn), a novel Drosophila gene required for tracheal tube elongation and lumen stability at larval stages. Larvae lacking Apn show abnormal tracheal inflation and twisted airway tubes, but no obvious defects in early steps of tracheal maturation. apn encodes a transmembrane protein, primarily expressed in the tracheae, which exerts its function by controlling the localization of Crumbs (Crb), an evolutionarily conserved apical determinant. Apn physically interacts with Crb to control its localization and maintenance at the apical membrane of developing airways. In apn mutant tracheal cells, Crb fails to localize apically and is trapped in retromer-positive vesicles. Consistent with the role of Crb in apical membrane growth, RNAi-mediated knockdown of Crb results in decreased apical surface growth of tracheal cells and impaired axial elongation of the dorsal trunk. We conclude that Apn is a novel regulator of tracheal tube expansion in larval tracheae, the function of which is mediated by Crb.
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Registered trials
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