Evidence map›Paper›PMID 30646157›Full record

SynthesisJAMA network open2018

Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis.

Kuan-Pin Su, Ping-Tao Tseng, Pao-Yen Lin, Ryo Okubo, Tien-Yu Chen, Yen-Wen Chen, Yutaka J Matsuoka

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JAMA network open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 10 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 10 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kuan-Pin SuDepartment of Psychiatry, China Medical University Hospital, Taichung, Taiwan.
Ping-Tao TsengWinShine Clinics in Specialty of Psychiatry, Kaohsiung City, Taiwan.
Pao-Yen LinDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Ryo OkuboDivision of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.
Tien-Yu ChenDepartment of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan.
Yen-Wen ChenProspect Clinic for Otorhinolaryngology & Neurology, Kaohsiung, Taiwan.
Yutaka J MatsuokaCollege of Medicine, China Medical University, Taichung, Taiwan.
National Center for Global Health and Medicine · JPChang Gung University · TWChina Medical University Hospital · TWNational Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: No systematic review or meta-analysis has assessed the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) for anxiety. Objective: To evaluate the association of anxiety symptoms with omega-3 PUFA treatment compared with controls in varied populations. Data Sources: PubMed, Embase, ProQuest, ScienceDirect, Cochrane Library, ClinicalKey, Web of Science, and ClinicalTrials.gov databases were searched up to March 4, 2018. Study Selection: A search was performed of clinical trials assessing the anxiolytic effect of omega-3 PUFAs in humans, in either placebo-controlled or non-placebo-controlled designs. Of 104 selected articles, 19 entered the final data extraction stage. Data Extraction and Measures: Two authors independently extracted the data according to a predetermined list of interests. A random-effects model meta-analysis was performed and this study was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Main Outcomes and Measures: Changes in the severity of anxiety symptoms after omega-3 PUFA treatment. Results: In total, 1203 participants with omega-3 PUFA treatment (mean age, 43.7 years; mean female proportion, 55.0%; mean omega-3 PUFA dosage, 1605.7 mg/d) and 1037 participants without omega-3 PUFA treatment (mean age, 40.6 years; mean female proportion, 55.0%) showed an association between clinical anxiety symptoms among participants with omega-3 PUFA treatment compared with control arms (Hedges g, 0.374; 95% CI, 0.081-0.666; P = .01). Subgroup analysis showed that the association of treatment with reduced anxiety symptoms was significantly greater in subgroups with specific clinical diagnoses than in subgroups without clinical conditions. The anxiolytic effect of omega-3 PUFAs was significantly better than that of controls only in subgroups with a higher dosage (at least 2000 mg/d) and not in subgroups with a lower dosage (<2000 mg/d). Conclusions and Relevance: This review indicates that omega-3 PUFAs might help to reduce the symptoms of clinical anxiety. Further well-designed studies are needed in populations in whom anxiety is the main symptom.

Indexed as

AdultAnxietyDietary SupplementsFatty Acids, Omega-3FemaleHumansMaleTreatment OutcomeFatty Acids, Omega-3

Identifiers

PMID30646157
PMCPMC6324500
OpenAlexW2889754600

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.