ArticleThe British journal of radiology2019
Intracranial aneurysms at higher clinical risk for rupture demonstrate increased wall enhancement and thinning on multicontrast 3D vessel wall MRI.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Intracranial vessel wall MRI to identify the culprit aneurysm in subarachnoid hemorrhage with multiple intracranial aneurysms.Emergency radiology · 2026Article
- Sequential rupture of multiple intracranial aneurysms with rapidSurgical neurology international · 2026Article
- Intracranial vessel wall lesions on MRI: anatomical and pathological issues.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Quantitative Analysis of Intracranial Atherosclerosis and Its Correlation with Ischemic Cerebrovascular Disease and Prognosis.Brain sciences · 2025Article
- Arterial wall enhancement indicates higher reperfusion rates in non-ruptured aneurysms after endovascular treatment with stent-assisted coiling.Neuroradiology · 2025Article
- DANTE-CAIPI Accelerated Contrast-Enhanced 3D T1: Deep Learning-Based Image Quality Improvement for Vessel Wall MRI.AJNR. American journal of neuroradiology · 2025Article
- Vessel wall image as a marker of cerebral aneurysm instability.Surgical neurology international · 2025Article
- Vessel wall imaging and quantitative flow assessment in arteriovenous malformations: A feasibility study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- Aneurysmal Wall Enhancement of Non-Ruptured Intracranial Aneurysms after Endovascular Treatment Correlates with Higher Aneurysm Reperfusion Rates, but Only in Large Aneurysms.Diagnostics (Basel, Switzerland) · 2024Article
- Delayed Enhancement of Intracranial Atherosclerotic Plaque Can Better Differentiate Culprit Lesions: A Multiphase Contrast-Enhanced Vessel Wall MRI Study.AJNR. American journal of neuroradiology · 2024Article
- Advanced cross-sectional imaging of cerebral aneurysms.The British journal of radiology · 2023Review
- Ruptured bilateral middle cerebral artery aneurysms diagnosed based on cerebral vasospasm-associated ischemic symptoms: A case report.Radiology case reports · 2022Article
- Idiopathic intracranial hypertension imaging approaches and the implications in patient management.The British journal of radiology · 2022Review
- Survey of the American Society of Neuroradiology Membership on the Use and Value of Intracranial Vessel Wall MRI.AJNR. American journal of neuroradiology · 2022Article
- Intracranial aneurysm wall (in)stability-current state of knowledge and clinical perspectives.Neurosurgical review · 2022Review
- High-Resolution Vessel Wall MRI of Endovascularly Treated Intracranial Aneurysms.Tomography (Ann Arbor, Mich.) · 2022Article
- Vessel Wall MR Imaging in the Pediatric Head and Neck.Magnetic resonance imaging clinics of North America · 2021Review
- An Image-Based Workflow for Objective Vessel Wall Enhancement Quantification in Intracranial Aneurysms.Diagnostics (Basel, Switzerland) · 2021Article
- Pseudo-Enhancement in Intracranial Aneurysms on Black-Blood MRI: Effects of Flow Rate, Spatial Resolution, and Additional Flow Suppression.Journal of magnetic resonance imaging : JMRI · 2021Article
- Double delay alternating with nutation for tailored excitation facilitates banding-free isotropic high-resolution intracranial vessel wall imaging.NMR in biomedicine · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
objective: Identification of aneurysms at risk for rupture is important and challenging. We sought to evaluate if intracranial vessel wall (IVW) imaging characteristics of unruptured aneurysms correlate with clinical risk factors for rupture.
methods: Patients with unruptured intracranial aneurysms were prospectively recruited and underwent a multi contrast 3D IVW protocol between April 6, 2016 and August 29, 2017. Two independent raters, blinded to aneurysm vulnerability, evaluated each aneurysm for wall enhancement, extent of enhancement in terms of the numbers of quadrants enhancing circumferentially, intensity of enhancement, and qualitative wall thinning. PHASES score was calculated for each aneurysm. Univariate logistic regression analysis was used to compare IVW characteristics between aneurysms at higher clinical risk for rupture (PHASES score > 3) and lower clinical risk for rupture (PHASES score ≤ 3).
results: 45 patients with 65 unruptured aneurysms were analyzed; 38 aneurysms with PHASES score > 3 (58%) and 27 aneurysms with PHASES score ≤ 3 (42%). Aneurysms with PHASES score > 3 were more likely to demonstrate enhancement (42.1% vs 14.8%, p = 0.022), greater extent of enhancement (mean: 2.9 vs 2.2 quadrants, p = 0.063), and wall thinning (9.2% vs 0%, p = 0.044). Inter-reader agreement was moderate-to-good for the presence (κ = 0.64), extent (κ = 0.64), and intensity of enhancement (κ = 0.60) but relatively low for wall thinning (κ = 0.25).
conclusion: Aneurysms at higher risk of rupture by PHASES score are more likely to demonstrate wall enhancement, more diffuse enhancement, and wall thinning on IVW. ADVANCES IN KNOWLEDGE:: This study prospectively compares IVW-detected wall enhancement and thinning between unruptured aneurysms stratified into high and low risk groups by clinical scores (PHASES) of vulnerability.
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