ArticleTranslational psychiatry2019
Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Article
- Phenome-wide study connects behavioral genetics of odor detection dogs with temperament traits.Scientific reports · 2026Article
- Investigating targeted and untargeted approaches to biomarker discovery in fearful, adult dogs.Journal of animal science · 2026Article
- Article
- Spina bifida, diplomyelia, and Chiari-like malformation in an Aberdeen Angus calf.BMC veterinary research · 2025Article
- Determinants of de novo mutations in extended pedigrees of 43 dog breeds.Genome biology · 2025Article
- Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study.PloS one · 2025Article
- Heritability and Genome-Wide Association Study of Dog Behavioral Phenotypes in a Commercial Breeding Cohort.Genes · 2024Article
- Therapy and Prevention of Noise Fears in Dogs-A Review of the Current Evidence for Practitioners.Animals : an open access journal from MDPI · 2023Review
- Modulation of dog-owner relationship and dog social and cognitive behavior by owner temperament and dog breed group.Scientific reports · 2023Article
- Genomic analysis of firework fear and noise reactivity in standard poodles.Canine medicine and genetics · 2023Article
- Ancestry-inclusive dog genomics challenges popular breed stereotypes.Science (New York, N.Y.) · 2022Article
- Personality traits associate with behavioral problems in pet dogs.Translational psychiatry · 2022Article
- Genome-Wide Association Studies Reveal Neurological Genes for Dog Herding, Predation, Temperament, and Trainability Traits.Frontiers in veterinary science · 2021Article
- Active and social life is associated with lower non-social fearfulness in pet dogs.Scientific reports · 2020Article
- A novel genomic region on chromosome 11 associated with fearfulness in dogs.Translational psychiatry · 2020Article
- Prevalence, comorbidity, and breed differences in canine anxiety in 13,700 Finnish pet dogs.Scientific reports · 2020Article
- Inadequate socialisation, inactivity, and urban living environment are associated with social fearfulness in pet dogs.Scientific reports · 2020Article
- A comprehensive biomedical variant catalogue based on whole genome sequences of 582 dogs and eight wolves.Animal genetics · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are among the leading health issues in human medicine. The complex phenotypic and allelic nature of these traits as well as the challenge of establishing reliable measures of the heritable component of behaviour from the associated environmental factors hampers progress in their molecular aetiology. Dogs exhibit large natural variation in fearful and anxious behaviour and could facilitate progress in the molecular aetiology due to their unique genetic architecture. We have performed a genome-wide association study with a canine high-density SNP array in a cohort of 330 German Shepherds for two phenotypes, fear of loud noises (noise sensitivity) and fear of strangers or in novel situations. Genome-widely significant loci were discovered for the traits on chromosomes 20 and 7, respectively. The regions overlap human neuropsychiatric loci, including 18p11.2, with physiologically relevant candidate genes that contribute to glutamatergic and dopaminergic neurotransmission in the brain. In addition, the noise-sensitivity locus includes hearing-related candidate genes. These results indicate a genetic contribution for canine fear and suggest a shared molecular aetiology of anxiety across species. Further characterisation of the identified loci will pave the way to molecular understanding of the conditions as a prerequisite for improved therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.