Evidence map›Paper›PMID 30656543›Full record

ReviewVeterinary research communications2019

Stem cells on regenerative and reproductive science in domestic animals.

Naira Caroline Godoy Pieri, Aline Fernanda de Souza, Ramon Cesar Botigelli, Lucas Simões Machado, Carlos Eduardo Ambrosio, Daniele Dos Santos Martins, André Furugen Cesar de Andrade, Flavio Vieira Meirelles, Poul Hyttel, Fabiana Fernandes Bressan

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Bovine Pluripotent Stem Cells: Current Status and Prospects.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Porcine Germ Cells Phenotype during Embryonic and Adult Development.Animals : an open access journal from MDPI · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. World journal of stem cells · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Naira Caroline Godoy PieriDepartment of Animal Reproduction, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
Aline Fernanda de SouzaDepartment of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Ramon Cesar BotigelliDepartment of Pharmacology, Institute of Biosciences, São Paulo State University, Botucatu, Brazil.
Lucas Simões MachadoDepartment of Surgery, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
Carlos Eduardo AmbrosioDepartment of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Daniele Dos Santos MartinsDepartment of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
André Furugen Cesar de AndradeDepartment of Animal Reproduction, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
Flavio Vieira MeirellesDepartment of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Poul HyttelDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Fabiana Fernandes BressanDepartment of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil. fabianabressan@usp.br.ORCID http://orcid.org/0000-0001-9862-5874
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversity of Copenhagen · DK

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038.006964/2014-43Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/01060-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/08135-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/09392-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/26818-5
6 · The paper itself

Abstract

Stem cells are undifferentiated and self-renewable cells that present new possibilities for both regenerative medicine and the understanding of early mammalian development. Adult multipotent stem cells are already widely used worldwide in human and veterinary medicine, and their therapeutic signalling, particularly with respect to immunomodulation, and their trophic properties have been intensively studied. The derivation of embryonic stem cells (ESCs) from domestic species, however, has been challenging, and the poor results do not reflect the successes obtained in mouse and human experiments. More recently, the generation of induced pluripotent stem cells (iPSCs) via the forced expression of specific transcription factors has been demonstrated in domestic species and has introduced new potentials in regenerative medicine and reproductive science based upon the ability of these cells to differentiate into a variety of cells types in vitro. For example, iPSCs have been differentiated into primordial germ-like cells (PGC-like cells, PGCLs) and functional gametes in mice. The possibility of using iPSCs from domestic species for this purpose would contribute significantly to reproductive technologies, offering unprecedented opportunities to restore fertility, to preserve endangered species and to generate transgenic animals for biomedical applications. Therefore, this review aims to provide an updated overview of adult multipotent stem cells and to discuss new possibilities introduced by the generation of iPSCs in domestic animals, highlighting the possibility of generating gametes in vitro via PGCL induction.

Indexed as

Animals, DomesticRegenerative MedicineReproductionAnimalsEmbryonic Stem CellsInduced Pluripotent Stem CellsStem Cell TransplantationCellular therapyDomestic animalsInduced reprogrammingiPSCs

Identifiers

PMID30656543
OpenAlexW2909495243

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.