Evidence map›Paper›PMID 30657658›Full record

ArticleJournal of psychiatry & neuroscience : JPN2019

Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation

Yu Fukuda, Teresa Katthagen, Lorenz Deserno, Leila Shayegan, Jakob Kaminski, Andreas Heinz, Florian Schlagenhauf

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Yu FukudaFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Teresa KatthagenFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Lorenz DesernoFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Leila ShayeganFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Jakob KaminskiFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Andreas HeinzFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Florian SchlagenhaufFrom the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).
Leipzig University · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEColumbia University · USFreie Universität Berlin · DEMax Planck Institute for Human Cognitive and Brain Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Working-memory impairment is a core cognitive dysfunction in people with schizophrenia and people at mental high risk. Recent imaging studies on working memory have suggested that abnormalities in prefrontal activation and in connectivity between the frontal and parietal regions could be neural underpinnings of the different stages of psychosis. However, it remains to be explored whether comparable alterations are present in people with subclinical levels of psychosis, as experienced by a small proportion of the general population who neither seek help nor show constraints in daily functioning. Methods: We compared 24 people with subclinical high delusional ideation and 24 people with low delusional ideation. Both groups performed an n-back working-memory task during functional magnetic resonance imaging. We characterized frontoparietal effective connectivity using dynamic causal modelling. Results: Compared to people who had low delusional ideation, people with high delusional ideation showed a significant increase in dorsolateral prefrontal activation during the working-memory task, as well as reduced working-memory-dependent parietofrontal effective connectivity in the left hemisphere. Group differences were not evident at the behavioural level. Limitations: The current experimental design did not distinguish among the working-memory subprocesses; it remains unexplored whether differences in connectivity exist at that level. Conclusion: These findings suggest that alterations in the working-memory network are also present in a nonclinical population with psychotic experiences who do not display cognitive deficits. They also suggest that alterations in working-memory-dependent connectivity show a putative continuity along the spectrum of psychotic symptoms.

Indexed as

AdultConnectomeDelusionsFemaleHumansMagnetic Resonance ImagingMaleMemory, Short-TermNerve NetParietal LobePrefrontal CortexYoung Adult

Identifiers

PMID30657658
PMCPMC6488486
OpenAlexW2942545986

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.