Evidence map›Paper›PMID 30659520›Full record

SynthesisJournal of nephrology2019

Effects of intradialytic aerobic exercise on hemodialysis patients: a systematic review and meta-analysis.

Nada Salhab, Mirey Karavetian, Jeroen Kooman, Enrico Fiaccadori, Cosette F El Khoury

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05207527 (Design and Effectiveness of Different Physical Exercise-based Interventions About Health Indicators and Quality of Life in Patients With Chronic Kidney Disease in Hemodialysis), which is not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 8 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05207527 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Design and Effectiveness of Different Physical Exercise-based Interventions About Health Indicators and Quality of Life in Patients With Chronic Kidney Disease in Hemodialysis

TypeinterventionalSponsorUniversidad del RosarioRan2025 to 2028Enrolled120ConditionsChronic Kidney DiseasesArmscardiovascular exercise, Muscle strength, Mixed
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  5. Effects of intradialytic exercise on health-related quality of life in patients undergoing maintenance haemodialysis: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Pooled it
  6. Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022
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  16. l-carnitine supplementation vs cycle ergometer exercise for physical activity and muscle status in hemodialysis patients: A randomized clinical trial.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Nada SalhabSchool of Nutrition and Translational Research in Metabolism, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. n.salhab@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0001-5305-2793
Mirey KaravetianDepartment of Health Sciences, College of Natural Health Sciences, Zayed University, Dubai, United Arab Emirates.ORCID http://orcid.org/0000-0001-5916-6740
Jeroen KoomanDepartment of Internal Medicine, Division of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands.
Enrico FiaccadoriInternal Medicine and Nephrology Department, Parma University Medical School, Parma, Italy.ORCID http://orcid.org/0000-0002-6532-7675
Cosette F El KhourySchool of Public Health and Primary Care, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-6935-2758
Maastricht University · NLMaastricht University Medical Centre · NLUniversity of Parma · ITZayed University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIntradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis efficiency, inflammatory status, vitamin D3, parathyroid hormone, intake of phosphate binders, mortality and hospitalization rate.

methodsPubmed, Medline (Ovid), Embase (Ovid), Cochrane, and Cinahl (EBSCO) databases were searched to retrieve studies up to June 12, 2018. A manual reference search was also performed. Studies were included if they evaluated (a) aerobic IDE effect on at least one of our study parameters, (b) adult hemodialysis patients, (c) patients for > 1 month.

resultsTwenty-two studies were retrieved (706 participants), of which 12 were eligible for meta-analysis. Aerobic IDE had a significant positive effect on the QOL physical component score (QOL-PSC) and on mental component score (QOL-MCS) of SF36, but not on serum phosphorus or Kt/V.

conclusionsIDE incorporation into clinical practice has a significant positive effect on QOL-PSC and QOL-MCS. In the reviewed studies, IDE did not result in any health hazard in hemodialysis patients. Nevertheless, future research should assess the long-term effectiveness and safety of IDE. The limitations of this review include the lack of quality analysis of the studies, the limited number of studies that could be included in the meta-analysis, the diversity in the exercise intensity, duration and modality, and the limited data for several outcomes. PROSPERO REGISTRATION ID: CRD42016052062.

Indexed as

Quality of LifeRenal DialysisChelating AgentsCholecalciferolC-Reactive ProteinExerciseHospitalizationHumansInflammationParathyroid HormonePhosphorusRenal Insufficiency, ChronicChelating AgentsCholecalciferolC-Reactive ProteinParathyroid HormonePhosphorusHemodialysisIntradialytic exerciseMeta-analysisPhosphorusQuality of life

Identifiers

PMID30659520
PMCPMC6588711
OpenAlexW2910596999

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.