Evidence map›Paper›PMID 30666231›Full record

ArticleFrontiers in endocrinology2018

Antigenic "Hot- Spots" on the TSH Receptor Hinge Region.

Simeng Sun, Sarawut Summachiwakij, Ora Schneck, Syed A Morshed, Risheng Ma, Rauf Latif, Terry F Davies

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cryo-EM: A new dawn in thyroid biology.Molecular and cellular endocrinology · 2021
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Simeng SunThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Sarawut SummachiwakijThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ora SchneckThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Syed A MorshedThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Risheng MaThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Rauf LatifThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Terry F DaviesThyroid Research Unit, Department of Medicine, James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
James J. Peters VA Medical Center · USIcahn School of Medicine at Mount Sinai · US

Funding

Small Molecules and Antibodies Interacting at the TSH ReceptorR01DK069713 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVIES, TERRY FRANCIS · 2006 to 2019
$5.6M
SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASER01DK052464 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI DAVIES, TERRY FRANCIS · 1997 to 2013
$3.0M
NIDDK NIH HHS R01 DK052464NIDDK NIH HHS R01 DK069713
6 · The paper itself

Abstract

The TSH receptor (TSHR) hinge region was previously considered an inert scaffold connecting the leucine-rich ectodomain to the transmembrane region of the receptor. However, mutation studies have established the hinge region to be an extended hormone-binding site in addition to containing a region which is cleaved thus dividing the receptor into

Indexed as

ectdomainGraves' disease (GD)hinge antibodiesneutral antibodiesTSH receptor

Identifiers

PMID30666231
PMCPMC6330735
OpenAlexW2910146626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.