Evidence map›Paper›PMID 30674470›Full record

ArticleBlood2019

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands.

Qiaozhi Wei, Philip E Boulais, Dachuan Zhang, Sandra Pinho, Masato Tanaka, Paul S Frenette

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Macrophages in Hematopoiesis and Related Blood Diseases.Genomics, proteomics & bioinformatics · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Exploring CD169Vaccines · 2025
    Review
  8. Erythroblast enucleation at a glance.Journal of cell science · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Structural and Functional Insights into GID/CTLH E3 Ligase Complexes.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Qiaozhi WeiRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research.ORCID 0000-0003-3062-5071
Philip E BoulaisRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research.
Dachuan ZhangRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research.
Sandra PinhoRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research.ORCID 0000-0002-5241-7364
Masato TanakaLaboratory of Immune Regulation, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Paul S FrenetteRuth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research.ORCID 0000-0003-0862-9922
Institute for Stem Cell Biology and Regenerative Medicine · INAlbert Einstein College of Medicine · USTokyo University of Pharmacy and Life Sciences · JP

Funding

In Vivo Sickle Cell Vasoocclusion: Adhesion MechanismsR01HL069438 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KELLY, LIBUSHA · 2001 to 2024
$9.5M
Regulation and function of hematopoietic stem cell nichesR01DK056638 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GRITSMAN, KIRA · 2000 to 2023
$8.7M
In vivo function of macrophage in healthy and diseased erythropoiesisR01HL116340 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRENETTE, PAUL S · 2012 to 2015
$1.7M
Mechanisms regulating the aging of HSC nichesR01DK112976 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRENETTE, PAUL S · 2018 to 2021
$1.5M
Evaluating neural circuitry of the bone marrowU01DK116312 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRENETTE, PAUL S · 2017 to 2019
$1.3M
NHLBI NIH HHS R01 HL069438NHLBI NIH HHS R01 HL116340NIDDK NIH HHS R01 DK056638NIDDK NIH HHS R01 DK112976NIDDK NIH HHS U01 DK116312
6 · The paper itself

Abstract

The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts (EBs), was first described decades ago and was recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and EBs remain unclear. Macrophage-EB attacher (Maea) has previously been suggested to mediate homophilic adhesion bounds bridging macrophages and EBs.

Indexed as

ErythropoiesisAnimalsAnimals, NewbornBone MarrowCell Adhesion MoleculesErythroblastsMacrophagesMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutVascular Cell Adhesion Molecule-1Cell Adhesion MoleculesVascular Cell Adhesion Molecule-1

Identifiers

PMID30674470
PMCPMC6418477
OpenAlexW2913813078

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.