Evidence map›Paper›PMID 30674575›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates.

Kee Thai Yeo, Paula Embury, Timothy Anderson, Peter Mungai, Indu Malhotra, Christopher King, James Kazura, Arlene Dent

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Maternal Immune Activation: Implications for Congenital Heart Defects.Clinical reviews in allergy & immunology · 2025
    Review
  3. Review
  4. Review
  5. Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021
    Review
  6. Article
  7. Mediterranean Diet: Lipids, Inflammation, and Malaria Infection.International journal of molecular sciences · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kee Thai YeoCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.
Paula EmburyCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.
Timothy AndersonCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-5384-275X
Peter MungaiCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.
Indu MalhotraCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-0144-1089
Christopher KingCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-3873-7860
James KazuraCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-6390-634X
Arlene DentCenter for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106; aed9@case.edu.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Immaculate Lillian Nankya · 1994 to 2026
$50.0M
Kruppel-Like Factor 2 Counters Vascular and Immunologic Dysfunction in Child Cerebral MalariaR01AI130131 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 2017 to 2021
$3.0M
HIV, Malaria and Neurobehavioral Development in Early ChildhoodR01MH080601 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI HOLDING, PENNY A · 2007 to 2011
$2.9M
B cell immunity in HIV exposed uninfected infants in KenyaR01AI098511 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI DENT, ARLENE · 2012 to 2015
$2.5M
NCATS NIH HHS UL1 TR000439NIAID NIH HHS L40 AI061961NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI098511NIAID NIH HHS R01 AI130131NIMH NIH HHS R01 MH080601
6 · The paper itself

Abstract

Infections during pregnancy can expose the fetus to microbial Ags, leading to inflammation that affects B cell development. Prenatal fetal immune priming may have an important role in infant acquisition of pathogen-specific immunity. We examined plasma proinflammatory biomarkers, the proportions of various B cell subsets, and fetal priming to tetanus vaccination in cord blood from human United States and Kenyan neonates. United States neonates had no identified prenatal infectious exposures, whereas Kenyan neonates examined had congenital CMV or mothers with prenatal HIV or

Indexed as

AdultB-Lymphocyte SubsetsCytomegalovirusFemaleHIVHumansInfantInfant, NewbornInflammationKenyaMalariaMalePregnancyYoung Adult

Identifiers

PMID30674575
PMCPMC6379806

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.