ReviewObesity (Silver Spring, Md.)2019
Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity.
Review in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Laparoscopic sleeve gastrectomy for obesity treatment in adolescents and young adults: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Evaluating potential predictors of weight loss response to liraglutide in adolescents with obesity: A post hoc analysis of the randomized, placebo-controlled SCALE Teens trial.Pediatric obesity · 2023Trial
- Efficacy of Dapagliflozin Combined with Lifestyle Intervention in Obesity Control.Computational and mathematical methods in medicine · 2022Trial
- Extinguishing the Fire: Treating Pediatric Type 2 Diabetes by Targeting Obesity Treatment.Diabetes care · 2025Review
- Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort.JAMA network open · 2025Article
- Review
- Obesity among college students in Oman: implications for health and academic performance.BMC public health · 2025Article
- Obesity Class and Severity of Metabolic Emergencies: A Single-Center Retrospective Five-Year Study.Healthcare (Basel, Switzerland) · 2025Article
- Psychosocial outcomes after adolescent metabolic and bariatric surgery: a narrative review of the literature.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Review
- Assessment and medical management of weight regain after adolescent metabolic and bariatric surgery: a narrative review.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Review
- Effects of multidisciplinary therapy on energy balance, inflammation, and metabolic diseases in adolescents with obesity: A narrative review.Annals of the New York Academy of Sciences · 2024Review
- Special considerations for the child with obesity: An Obesity Medicine Association (OMA) clinical practice statement (CPS) 2024.Obesity pillars · 2024Article
- Effective and appropriate use of weight loss medication in pediatric obesity: a narrative review.Journal of Yeungnam medical science · 2024Article
- Obesity in Children and Adolescents: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.Journal of obesity & metabolic syndrome · 2024Review
- The need for increasing pediatric obesity advocacy.Complementary therapies in medicine · 2024Article
- Diagnosis and Management of Hypertension in Adolescents with Obesity.Current cardiovascular risk reports · 2024Review
- Editorial: New and old strategies to curb the obesity epidemic in children.Frontiers in pediatrics · 2024Article
- Management of pediatric obesity as a pathway towards kidney transplantation.Frontiers in pediatrics · 2024Review
- Diagnostic challenge: A pediatric patient with severe obesity and complications of imminent death.Obesity pillars · 2023Article
- Cost-Effectiveness of Pharmacotherapy for the Treatment of Obesity in Adolescents.JAMA network open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
A growing number of youth suffer from obesity and in particular severe obesity for which intensive lifestyle intervention does not adequately reduce excess adiposity. A treatment gap exists wherein effective treatment options for an adolescent with severe obesity include intensive lifestyle modification or metabolic and bariatric surgery while the application of obesity pharmacotherapy remains largely underutilized. These youth often present with numerous obesity-related comorbid diseases, including hypertension, dyslipidemia, prediabetes/type 2 diabetes, obstructive sleep apnea, nonalcoholic fatty liver disease, musculoskeletal problems, and psychosocial issues such as depression, anxiety, and social stigmatization. Current pediatric obesity treatment algorithms for pediatric primary care providers focus primarily on intensive lifestyle intervention with escalation of treatment intensity through four stages of intervention. Although a recent surge in the number of Food and Drug Administration-approved medications for obesity treatment has emerged in adults, pharmacotherapy options for youth remain limited. Recognizing treatment and knowledge gaps related to pharmacological agents and the urgent need for more effective treatment strategies in this population, discussed here are the efficacy, safety, and clinical application of obesity pharmacotherapy in youth with obesity based on current literature. Legal ramifications, informed consent regulations, and appropriate off-label use of these medications in pediatrics are included, focusing on prescribing practices and prescriber limits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.