ArticlePsychological medicine2020
Translating a rodent measure of negative bias into humans: the impact of induced anxiety and unmedicated mood and anxiety disorders.
Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Psychometrics of drift-diffusion model parameters derived from the Eriksen flanker task: Reliability and validity in two independent samples.Cognitive, affective & behavioral neuroscience · 2025Article
- Reward Sensitivity and Noise Contribute to Negative Affective Bias: A Learning Signal Detection Theory Approach in Decision-Making.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Test-Retest Reliability of Two Computationally-Characterised Affective Bias Tasks.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Updating Prospective Self-Efficacy Beliefs About Cardiac Interoception in Anorexia Nervosa: An Experimental and Computational Study.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Affect-congruent attention modulates generalized reward expectations.PLoS computational biology · 2023Article
- Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching.Biological psychiatry global open science · 2023Article
- Anxiety as a disorder of uncertainty: implications for understanding maladaptive anxiety, anxious avoidance, and exposure therapy.Cognitive, affective & behavioral neuroscience · 2023Article
- Identifying Transdiagnostic Mechanisms in Mental Health Using Computational Factor Modeling.Biological psychiatry · 2023Review
- Computational Modeling of Self-Referential Processing Reveals Domain General Associations with Adolescent Anxiety Symptoms.Research on child and adolescent psychopathology · 2023Article
- Computational perspectives on human fear and anxiety.Neuroscience and biobehavioral reviews · 2023Review
- Association Between a Directly Translated Cognitive Measure of Negative Bias and Self-reported Psychiatric Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Under Threat, Weaker Evidence Is Required to Reach Undesirable Conclusions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Computational modelling of attentional bias towards threat in paediatric anxiety.Developmental science · 2021Article
- The Importance of Common Currency Tasks in Translational Psychiatry.Current behavioral neuroscience reports · 2021Review
- Affective Bias Through the Lens of Signal Detection Theory.Computational psychiatry (Cambridge, Mass.) · 2021Article
- Ventromedial Prefrontal Cortex Activity and Sympathetic Allostasis During Value-Based Ambivalence.Frontiers in behavioral neuroscience · 2021Article
- "Bigger" or "better": the roles of magnitude and valence in "affective bias".Cognition & emotion · 2020Article
- Learning and Choice in Mood Disorders: Searching for the Computational Parameters of Anhedonia.Computational psychiatry (Cambridge, Mass.) · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMood and anxiety disorders are ubiquitous but current treatment options are ineffective for many sufferers. Moreover, a number of promising pre-clinical interventions have failed to translate into clinical efficacy in humans. Improved treatments are unlikely without better animal-human translational pipelines. Here, we translate a rodent measure of negative affective bias into humans, exploring its relationship with (1) pathological mood and anxiety symptoms and (2) transient induced anxiety.
methodsAdult participants (age = 29 ± 11) who met criteria for mood or anxiety disorder symptomatology according to a face-to-face neuropsychiatric interview were included in the symptomatic group. Study 1 included N = 77 (47 = asymptomatic [female = 21]; 30 = symptomatic [female = 25]), study 2 included N = 47 asymptomatic participants (25 = female). Outcome measures were choice ratios, reaction times and parameters recovered from a computational model of reaction time - the drift diffusion model (DDM) - from a two-alternative-forced-choice task in which ambiguous and unambiguous auditory stimuli were paired with high and low rewards.
resultsBoth groups showed over 93% accuracy on unambiguous tones indicating intact discrimination, but symptomatic individuals demonstrated increased negative affective bias on ambiguous tones [proportion high reward = 0.42 (s.d. = 0.14)] relative to asymptomatic individuals [0.53 (s.d. = 0.17)] as well as a significantly reduced DDM drift rate. No significant effects were observed for the within-subjects anxiety-induction.
conclusionsHumans with pathological anxiety symptoms directly mimic rodents undergoing anxiogenic manipulation. The lack of sensitivity to transient anxiety suggests the paradigm might be more sensitive to clinically relevant symptoms. Our results establish a direct translational pipeline (and candidate therapeutics screen) from negative affective bias in rodents to pathological mood and anxiety symptoms in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.