Evidence map›Paper›PMID 30683901›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2019

Lens-specific conditional knockout of Msx2 in mice leads to ocular anterior segment dysgenesis via activation of a calcium signaling pathway.

Wenting Yu, Ziyan Yu, Danhong Wu, Jiao Zhang, Ying Zhu, Yang Zhang, Hong Ning, Mingwu Wang, Jinsong Zhang, Jiangyue Zhao

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wenting YuDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China.
Ziyan YuDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China.
Danhong WuDepartment of Neurology, Shanghai Fifth People's Hospital, Fudan University, 200240, Shanghai, China.
Jiao ZhangDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China.
Ying ZhuDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China.
Yang ZhangDepartment of Ophthalmology, The First Affiliated Hospital, China Medical University, 110001, Shenyang, China.
Hong NingDepartment of Ophthalmology, The First Affiliated Hospital, China Medical University, 110001, Shenyang, China.
Mingwu WangDepartment of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ, 85711, USA.
Jinsong ZhangDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China.
Jiangyue ZhaoDepartment of Ophthalmology, The Fourth Affiliated Hospital, China Medical University, 110005, Shenyang, China. jyzhao@cmu.edu.cn.
China Medical University · CNFourth Affiliated Hospital of China Medical University · CNFudan University · CNUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocular anterior segment dysgenesis (ASD) is a failure of normal development of anterior structures of the eye, leading to lens opacification. The underlying mechanisms relating to ASD are still unclear. Previous studies have implicated transcriptional factor muscle segment homeobox 2 (Msx2) in ASD. In this study, we used Msx2 conditional knockout (CKO) mice as a model and found that Msx2 deficiency in surface ectoderm induced ASD. Loss of Msx2 function specifically affected lens development, while other eye structures were not significantly affected. Multiple lines of evidence show that calcium signaling pathways are involved in this pathogenesis. Our study demonstrates that Msx2 plays an essential role in lens development by activating a yet undetermined calcium signaling pathway.

Indexed as

AnimalsApoptosisCalcium SignalingCell ProliferationCrystallinsEctodermEye AbnormalitiesFemaleGene ExpressionGene Knockout TechniquesHomeodomain ProteinsLens, CrystallineMaleMiceMice, Inbred BALB CMice, Inbred C57BLCrystallinsHomeodomain ProteinsMSX2 protein

Identifiers

PMID30683901
OpenAlexW2913384838

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.