Evidence map›Paper›PMID 30687330›Full record

ReviewFrontiers in immunology2018

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?

Matteo Vecellio, Carla J Cohen, Amity R Roberts, Paul B Wordsworth, Tony J Kenna

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Recent Updates in Juvenile Spondyloarthritis.Rheumatic diseases clinics of North America · 2021
    Review
  11. Regulatory effects of miR-138 and RUNX3 on Th1/Th2 balance in peripheral blood of children with cough variant asthma.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Integration ofFrontiers in immunology · 2021
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Matteo VecellioNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Carla J CohenNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Amity R RobertsDunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Paul B WordsworthNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Tony J KennaTranslational Research Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia.
University of Oxford · GBNuffield Orthopaedic Centre · GBPrincess Alexandra Hospital · AU

Funding

Arthritis Research UK 18797Arthritis Research UK 19536Arthritis Research UK 20402Arthritis Research UK 20796Arthritis Research UK 21428
6 · The paper itself

Abstract

Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include

Indexed as

AminopeptidasesCD8-Positive T-LymphocytesCore Binding Factor Alpha 3 SubunitGene Expression RegulationHLA-B27 AntigenHumansImmunologic FactorsInterleukin-23Killer Cells, NaturalMolecular Targeted TherapyPolymorphism, Single NucleotideReceptors, InterleukinSpondylitis, AnkylosingT-bet Transcription FactorT-Box Domain ProteinsAminopeptidasesCore Binding Factor Alpha 3 SubunitHLA-B27 AntigenImmunologic FactorsInterleukin-23Receptors, InterleukinRunx3 protein, humanT-bet Transcription FactorT-Box Domain Proteinsankylosing spondylitisautoimmunityfunctional genomicsinflammationtherapy

Identifiers

PMID30687330
PMCPMC6335330
OpenAlexW2909118704

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.