Evidence map›Paper›PMID 30688410›Full record

Trial reportJournal of diabetes investigation2019

Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: A randomized cross-over pilot study.

Daisuke Sato, Katsutaro Morino, Seiichiro Ogaku, Akiko Tsuji, Kimihiro Nishimura, Osamu Sekine, Satoshi Ugi, Hiroshi Maegawa

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Role of the Gut in Diabetic Dyslipidemia.Frontiers in endocrinology · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Daisuke SatoDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.ORCID https://orcid.org/0000-0002-1239-8947
Katsutaro MorinoDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.ORCID https://orcid.org/0000-0003-2420-3817
Seiichiro OgakuDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Akiko TsujiDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Kimihiro NishimuraDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Osamu SekineDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Satoshi UgiDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Hiroshi MaegawaDepartment of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.
Shiga University of Medical Science · JP

Funding

Shiga University of Medical Science
6 · The paper itself

Abstract

AIMS/

introductionPreprandial metformin administration significantly reduces postprandial plasma triglyceride levels in animal studies by reducing intestinal absorption through delayed gastric emptying. However, this effect has not been shown in a clinical study. Therefore, we planned to investigate the efficacy of preprandial metformin administration on postprandial hypertriglyceridemia and the related gastrointestinal effects in patients with type 2 diabetes mellitus. MATERIALS AND

methodsA total of 11 patients taking single-dose metformin at 500-1,000 mg, with non-fasting plasma triglyceride levels of 150-1,000 mg/dL, were recruited at a single university hospital. The difference between preprandial and postprandial metformin administration on postprandial hypertriglyceridemia was examined by a meal test. The gastrointestinal effects of metformin, including stomach heaviness, heartburn and satiety, were also assessed using a visual analog scale.

resultsThe mean bodyweight of patients was 80.6 kg (body mass index 27.9 kg/m

conclusionsPreprandial metformin administration significantly reduced plasma triglyceride level during meal testing without marked exacerbation of gastrointestinal adverse effects. The present results suggest that a simple change in the timing of metformin administration represents a novel approach for enhancing triglyceride-lowering strategies in patients with type 2 diabetes mellitus and postprandial hypertriglyceridemia.

Indexed as

Time-to-TreatmentBiomarkersBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansHypertriglyceridemiaHypoglycemic AgentsMaleMetforminMiddle AgedPilot ProjectsPostprandial PeriodBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsMetforminTriglyceridesGastric emptyingMetforminPostprandial hypertriglyceridemia

Identifiers

PMID30688410
PMCPMC6717824
OpenAlexW2911948333

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.