Evidence map›Paper›PMID 30697482›Full record

ArticlePeerJ2019

Association of TIMP4 gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China.

Jiaqi Wang, Feimeng An, Yuju Cao, Hongyan Gao, Mingqi Sun, Chao Ma, Hao Wu, Baoxin Zhang, Wanlin Liu, Jianzhong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Steroid-induced osteonecrosis.Journal of translational autoimmunity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jiaqi Wang *Inner Mongolia Medical University, Hohhot, China.
Feimeng An *Inner Mongolia Medical University, Hohhot, China.
Yuju CaoZhengzhou Traditional Chinese Medicine Traumatology Hospital, Zhengzhou, China.
Hongyan GaoThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Mingqi SunThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Chao MaThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Hao WuThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Baoxin ZhangThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Wanlin LiuThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jianzhong WangThe Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Second Affiliated Hospital of Inner Mongolia Medical University · CNInner Mongolia Medical University · CNZhengzhou City Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn clinical treatment, the use of steroid hormones is an important etiological factor of non-traumatic osteonecrosis of the femoral head (ONFH) risk. As an endogenous inhibitor of matrix metalloproteinases (MMPs) in the extracellular matrix, the expression of tissue inhibitors of metalloprotease-4 (TIMP4) plays an essential role in cartilage and bone tissue damage and remodeling, vasculitis formation, intravascular thrombosis, and lipid metabolism.

methodsThis study aimed to detect the association between TIMP4 polymorphism and steroid-induced ONFH. We genotyped seven single-nucleotide polymorphisms (SNPs) in TIMP4 genes and analyzed the association with steroid-induced ONFH from 286 steroid-induced ONFH patients and 309 normal individuals.

resultsWe performed allelic model analysis and found that the minor alleles of five SNPs (rs99365, rs308952, rs3817004, rs2279750, and rs3755724) were associated with decreased steroid-induced ONFH (

conclusionOur results indicate that five TIMP4 SNPs (rs99365, rs308952, rs3817004 rs2279750, and rs3755724) are significantly associated with decreased risk of steroid-induced ONFH in the population of northern China.

Indexed as

Association studyClinical phenotypesGene variantsOsteonecrosis of the femoral headSingle-nucleotide polymorphismsTissue inhibitors of metalloprotease-4

Identifiers

PMID30697482
PMCPMC6348097
OpenAlexW2914116837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.