Evidence map›Paper›PMID 30697591›Full record

ArticleNeurology. Genetics2019

Gene variants of adhesion molecules predispose to MS: A case-control study.

Efthimios Dardiotis, Elena Panayiotou, Vasileios Siokas, Athina-Maria Aloizou, Kyproula Christodoulou, Andreas Hadjisavvas, Marios Pantzaris, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, Theodoros Kyriakides

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Frontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Efthimios DardiotisCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Elena PanayiotouCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Vasileios SiokasCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Athina-Maria AloizouCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Kyproula ChristodoulouCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Andreas HadjisavvasCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Marios PantzarisCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Nikolaos GrigoriadisCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Georgios M HadjigeorgiouCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
Theodoros KyriakidesCyprus Institute of Neurology and Genetics (E.D., E.P., K.C., A.H., M.P., T.K.), Nicosia; Department of Neurology, Laboratory of Neurogenetics (E.D., V.S., A.-M.A.), University of Thessaly, University Hospital of Larissa; Cyprus School of Molecular Medicine (E.P., K.C., A.H., T.K.), Nicosia; 2nd Department of Neurology (N.G.), AHEPA University Hospital, Aristotle University of Thessaloniki; and Department of Neurology (G.M.H.), Medical School, University of Cyprus, Nicosia, Greece.
AHEPA University Hospital · GRCyprus Institute of Neurology and Genetics · CYAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the development of MS.

methodsA total of 389 Greek MS cases and 336 controls were recruited by 3 MS centers in Cyprus and Greece. In total, 147 tagging single nucleotide polymorphisms across 9 genes encoding for P-selectin (

resultsOverall, 21 variants across

conclusionsThe current study provides preliminary evidence that variants across genes encoding adhesion molecules, responsible for lymphocyte adhesion and trafficking within the CNS, are implicated in the risk of developing MS.

Identifiers

PMID30697591
PMCPMC6340332
OpenAlexW2908729461

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.