Evidence map›Paper›PMID 30697944›Full record

Observational studyJournal of the International AIDS Society2019

Diabetes mellitus burden among people living with HIV from the Asia-Pacific region.

Win M Han, Awachana Jiamsakul, Sasisopin Kiertiburanakul, Oon T Ng, Benedict Lh Sim, Ly P Sun, Kinh Van Nguyen, Jun Y Choi, Man P Lee, Wing W Wong and 14 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  7. Integrase Strand Transfer Inhibitor-Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  8. Article
  9. Risks of Type 2 diabetes among older people living with HIV: A scoping review.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 13 countries.

Win M HanHIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand.ORCID 0000-0003-3731-7960
Awachana JiamsakulThe Kirby Institute, UNSW, Sydney, Australia.
Sasisopin KiertiburanakulFaculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Oon T NgTan Tock Seng Hospital, Singapore, Singapore.
Benedict Lh SimHospital Sungai Buloh, Sungai Buloh, Malaysia.
Ly P SunNational Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia.
Kinh Van NguyenNational Hospital for Tropical Diseases, Hanoi, Vietnam.
Jun Y ChoiDivision of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.ORCID 0000-0002-2775-3315
Man P LeeQueen Elizabeth Hospital, Hong Kong SAR.
Wing W WongTaipei Veterans General Hospital, Taipei, Taiwan.
Adeeba KamarulzamanUniversity Malaya Medical Centre, Kuala Lumpur, Malaysia.
Nagalingeswaran KumarasamyChennai Antiviral Research and Treatment Clinical Research Site (CART CRS), YRGCARE Medical Centre, VHS, Chennai, India.
Fujie ZhangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Junko TanumaNational Center for Global Health and Medicine, Tokyo, Japan.ORCID 0000-0002-1697-7364
Cuong D DoBach Mai Hospital, Hanoi, Vietnam.
Romanee ChaiwarithResearch Institute for Health Sciences, Chiang Mai, Thailand.
Tuti P MeratiFaculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia.
Evy YunihastutiFaculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Sanjay PujariInstitute of Infectious Diseases, Pune, India.
Rossana DitangcoResearch Institute for Tropical Medicine, Muntinlupa City, Philippines.
Suwimon KhusuwanChiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
Jeremy RossTREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Anchalee AvihingsanonHIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand.ORCID 0000-0003-3222-9611
IeDEA Asia-Pacific
Bạch Mai Hospital · VNCapital Medical University · CNChiangRai Prachanukroh Hospital · THChulalongkorn University · THHIV Netherlands Australia Thailand Research Collaboration · THHospital for Tropical Diseases · VNHospital Sungai Buloh · MYMahidol University · THNational Center for Global Health and Medicine · JPNational Center for HIV/AIDS, Dermatology and STD · KHQueen Elizabeth Hospital · CNResearch Institute for Tropical Medicine · PHSerum Institute of India (India) · INTaipei Veterans General Hospital · TWTan Tock Seng Hospital · SGUdayana University · IDUniversity Malaya Medical Centre · MYUniversity of Indonesia · IDUNSW Sydney · AUYonsei University · KR

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

introductionComorbidities including diabetes mellitus (DM) among people living with HIV (PLHIV) are of increasing clinical concerns in combination antiretroviral therapy (cART) era. We aimed to determine the incidence and risk factors of new-onset DM among PLHIV in Asian settings.

methodsPLHIV from a regional observational cohort without DM prior to antiretroviral therapy (ART) initiation were included in the analysis. DM was defined as having a fasting blood glucose ≥126 mg/dL, glycated haemoglobin ≥6.5%, a two-hour plasma glucose ≥200 mg/dL, or a random plasma glucose ≥200 mg/dL. A Cox regression model, stratified by site, was used to identify risk factors associated with DM. RESULTS AND DISCUSSION: Of the 1927 participants included, 127 were diagnosed with DM after ART initiation. Median follow-up time from ART initiation to DM diagnosis was 5.9 years (interquartile range (IQR): 2.8 to 8.9 years). The crude incidence rate of DM was 1.08 per 100 person-years (100 PYS), 95% confidence interval (CI) (0.9 to 1.3). In the multivariate analysis, later years of follow-up (2011 to 2013: HR = 2.34, 95% CI 1.14 to 4.79, p = 0.02; and 2014 to 2017: HR = 7.20, 95% CI 3.27 to 15.87, p < 0.001) compared to <2010, older age (41 to 50 years: HR = 2.46, 95% CI 1.39 to 4.36, p  = 0.002; and >50 years: HR = 4.19, 95% CI 2.12 to 8.28, p < 0.001) compared to <30 years, body mass index (BMI) >30 kg/m

conclusionsType 2 DM in HIV-infected Asians was associated with later years of follow-up, high blood pressure, obesity and older age. This highlights the importance of monitoring and routine screening for non-communicable diseases including DM as PLHIV age.

Indexed as

AdultAnti-HIV AgentsAnti-Retroviral AgentsAsiaBlood GlucoseCohort StudiesDiabetes MellitusFemaleGlycated HemoglobinHIV InfectionsHumansMaleMiddle AgedRisk FactorsAnti-HIV AgentsAnti-Retroviral AgentsBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanantiretroviral therapyAsia-Pacificcomorbiditiesdiabetes mellitusnon-communicable diseasesvirologically suppressed PLHIV

Identifiers

PMID30697944
PMCPMC6351701
OpenAlexW2913548118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.