Evidence map›Paper›PMID 30700014›Full record

ArticleGenes2019

H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes.

Robin L Armstrong, Taylor J R Penke, Samuel K Chao, Gabrielle M Gentile, Brian D Strahl, A Gregory Matera, Daniel J McKay, Robert J Duronio

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Robin L ArmstrongCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. rarmst02@email.unc.edu.
Taylor J R PenkeCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. taylorpenke@gmail.com.
Samuel K ChaoDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599, USA. samuelkevinchao@gmail.com.
Gabrielle M GentileCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. gmarieg@live.unc.edu.
Brian D StrahlCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. brian_strahl@med.unc.edu.
A Gregory MateraCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. matera@unc.edu.
Daniel J McKayCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. dmckay1@email.unc.edu.ORCID 0000-0001-8226-0604
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. duronio@med.unc.edu.ORCID 0000-0001-6469-6965
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Regulation of Metazoan DNA Replication by ChromatinR01GM124201 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J · 2018 to 2021
$1.2M
Epigenetic control of metazoan transcription and pre-mRNA processing by histone PTMsR01GM129132 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATERA, A. GREGORY · 2018 to 2019
$899k
Investigating the Role of Histone Modifications in Heterochromatin FormationF31GM115194 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PENKE, TAYLOR JOEL RICHARD · 2015 to 2017
$84k
NCI NIH HHS P30 CA016086NIGMS NIH HHS F31-GM115194NIGMS NIH HHS R01 GM124201NIGMS NIH HHS R01-GM124201NIGMS NIH HHS R01 GM129132NIGMS NIH HHS R35 GM128851NIGMS NIH HHS T32-GM007092
6 · The paper itself

Abstract

Chromatin structure and its organization contributes to the proper regulation and timing of DNA replication. Yet, the precise mechanism by which chromatin contributes to DNA replication remains incompletely understood. This is particularly true for cell types that rely on polyploidization as a developmental strategy for growth and high biosynthetic capacity. During

Indexed as

DNA ReplicationAnimalsCentromereDrosophila melanogasterHeterochromatinHistonesMethylationPolytene ChromosomesProtein Processing, Post-TranslationalSalivary GlandsHeterochromatinHistonesDrosophilaEndoreplicationH3K9H4K16heterochromatinunder-replication

Identifiers

PMID30700014
PMCPMC6409945
OpenAlexW2914565910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.