ReviewInternational journal of molecular sciences2019
Acute and Chronic Effects of Cocaine on Cardiovascular Health.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06177860 (Clinical Presentation, Coronary Angiographic Findings and Extent of Atherosclerotic Disease in Patients With Acute Coronary Syndrome Associated With Cocaine Use), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Presentation, Coronary Angiographic Findings and Extent of Atherosclerotic Disease in Patients With Acute Coronary Syndrome Associated With Cocaine Use
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Children's exposure to cocaine detected by hair analysis: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Characterization and stratification of risk factors of stroke in people living with HIV: A theory-informed systematic review.BMC cardiovascular disorders · 2025Pooled it
- Three-year cardiovascular risk prediction among people who use cocaine or methamphetamine.Drug and alcohol dependence reports · 2026Article
- Elevated Cardiovascular Risk and Mortality in Type 2 Diabetes Mellitus Patients With Cannabis, Opioid, and Cocaine Use Disorders.Diabetes, obesity & metabolism · 2026Article
- Rising trends in mortality due to cocaine use and cardiovascular diseases in the United States: a retrospective analysis.Annals of medicine and surgery (2012) · 2026Article
- Cocaine-Induced Ocular Toxicity.Diseases (Basel, Switzerland) · 2026Review
- Acute Coronary Syndrome and Recreational Drug Use: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2026Review
- Comparative effectiveness of social-contextual treatments for improving substance-related problems among Black adults: An individual-level data synthesis.Addiction (Abingdon, England) · 2026Article
- Incidence of new-onset cardiac arrhythmias in cocaine and cannabis users: a retrospective cohort study.European heart journal. Acute cardiovascular care · 2026Article
- Superficial vein thrombosis of the upper extremity after pectoralis major repair: An uncommon complication.Trauma case reports · 2026Article
- Cocaine Use Disorder: Neuropathology and Exploratory Treatments.Molecular neurobiology · 2026Review
- Prevalence and Impact of Substance Use on Hospitalization and Post-Discharge Outcomes in Individuals with Congestive Heart Failure: Findings from a Safety-Net Hospital.International journal of environmental research and public health · 2025Article
- Guideline for Chronic Coronary Syndrome - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Determinants of the willingness to reduce or quit cocaine use among nightlife attendees.Archives of public health = Archives belges de sante publique · 2025Article
- Association of substance use with stroke in heart failure by community socioeconomic distress.Drug and alcohol dependence · 2025Article
- Myocardical Infarction in Young Adults: Revisiting Risk Factors and Atherothrombotic Pathways.Medicina (Kaunas, Lithuania) · 2025Review
- Cocaine and the heart - bad news for risk/reward.Journal of molecular and cellular cardiology plus · 2025Article
- Cocaine abuse and its impact on the thymus and spleen.Histology and histopathology · 2025Review
- Ischemic and non-ischemic myocardial injuries at autopsy- an overview for forensic pathologists.International journal of legal medicine · 2025Review
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac complications resulting from cocaine use have been extensively studied because of the complicated pathophysiological mechanisms. This study aims to review the underlying cellular and molecular mechanisms of acute and chronic effects of cocaine on the cardiovascular system with a specific focus on human studies. Studies have consistently reported the acute effects of cocaine on the heart (e.g., electrocardiographic abnormalities, acute hypertension, arrhythmia, and acute myocardial infarction) through multifactorial mechanisms. However, variable results have been reported for the chronic effects of cocaine. Some studies found no association of cocaine use with coronary artery disease (CAD), while others reported its association with subclinical coronary atherosclerosis. These inconsistent findings might be due to the heterogeneity of study subjects with regard to cardiac risk. After cocaine use, populations at high risk for CAD experienced coronary atherosclerosis whereas those at low risk did not experience CAD, suggesting that the chronic effects of cocaine were more likely to be prominent among individuals with higher CAD risk. Studies also suggested that risky behaviors and cardiovascular risks may affect the association between cocaine use and mortality. Our study findings highlight the need for education regarding the deleterious effects of cocaine, and access to interventions for cocaine abusers.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.