ArticleNature2019
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 129 citations in OpenAlex.
- Vericiguat Therapy Is Associated with Reverse Myocardial Remodeling in Chronic Heart Failure with Reduced Ejection Fraction.Journal of cardiovascular development and disease · 2025Article
- PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdomyosarcoma.Nature communications · 2025Article
- Targeting the NO-sGC-cGMP Pathway: Mechanisms of Action of Vericiguat in Chronic Heart Failure.Cells · 2025Review
- Evolution of growth factor signaling to the TSC complex to regulate mTORC1.Science signaling · 2025Review
- Occult epidermal growth factor receptor-mutant lung adenocarcinoma complicated by prostatic metastasis: a case report.Anti-cancer drugs · 2025Article
- Review
- GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice.Nature communications · 2025Article
- Influence of Soluble Guanylate Cyclase on Cardiac, Vascular, and Renal Structure and Function: A Physiopathological Insight.International journal of molecular sciences · 2025Review
- Cyclic nucleotide phosphodiesterases as drug targets.Pharmacological reviews · 2025Review
- In Silico Discovery of a Novel Natural Product Targeting PI3Kα for the Treatment of Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2025Article
- Identification and validation of hypoxia-responsive signature pathways in human cardiomyocytes.3 Biotech · 2025Article
- Promoting proteostasis by cAMP/PKA and cGMP/PKG.Trends in molecular medicine · 2025Review
- Cardiac cGMP Regulation and Therapeutic Applications.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Programmed Cell Death in Rheumatoid Arthritis.Journal of inflammation research · 2025Review
- Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics.Annual review of pharmacology and toxicology · 2025Review
- The multifaceted role of autophagy and mitophagy in cardiovascular health and disease.Autophagy reports · 2025Review
- New insights into tuberous sclerosis complex: from structure to pathogenesis.Frontiers in cell and developmental biology · 2025Review
- Bifidobacterium pseudolongum-Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP-PKG-mTORC1 Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Phosphorylation-Dependent Regulation of Guanylyl Cyclase (GC)-A and Other Membrane GC Receptors.Endocrine reviews · 2024Review
- SCFAutophagy · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Mark J RanekDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Kristen M Kokkonen-SimonDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Anna ChenDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Brittany L Dunkerly-EyringDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA.
Miguel Pinilla VeraDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Christian U OeingDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Chirag H PatelBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Taishi NakamuraDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Guangshuo ZhuDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Djahida BedjaDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Masayuki SasakiDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Ronald J HolewinskiThe Smidt Heart Institute and Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Jennifer E Van EykThe Smidt Heart Institute and Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Jonathan D PowellBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dong Ik LeeDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
David A KassDivision of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. dkass@jhmi.edu.
Johns Hopkins University · USBloomberg (United States) · USCedars-Sinai Medical Center · USCedars-Sinai Smidt Heart Institute · US
Funding
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2MLeveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3MA central role for mTOR in Determining T Cell Activation versus ToleranceR01AI077610 · NIAID · JOHNS HOPKINS UNIVERSITY · PI POWELL, JONATHAN D · 2009 to 2019
$4.0MTargeting Tumor Metabolism as a Means of Enhancing ImmunotherapyR01CA226765 · NCI · JOHNS HOPKINS UNIVERSITY · PI LEONE, ROBERT DAVID · 2019 to 2023
$1.9MRegulation of Cardiac Stress Responses by PDE5aR01HL089297 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2008 to 2011
$1.8MTransplantation tolerance and immune function following mTOR inhibition.R01AI091481 · NIAID · JOHNS HOPKINS UNIVERSITY · PI POWELL, JONATHAN D · 2010 to 2013
$1.6MPKG Redox Modulation of Cardiac Function and DiseaseR01HL119012 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2013 to 2016
$1.6MRole of Tuberin S1365 Phosphorylation in mTORC1 RegulationF31HL143905 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DUNKERLY-EYRING, BRITTANY · 2018 to 2020
$133kRole and Mechanisms of cGMP-PDE Compartmentation in Cardiac StressF31HL134196 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOKKONEN-SIMON, KRISTEN · 2016 to 2018
$125kNCI NIH HHS R01 CA226765NHLBI NIH HHS F31 HL134196NHLBI NIH HHS F31 HL143905NHLBI NIH HHS HHSN268201000032CNHLBI NIH HHS R01 HL089297NHLBI NIH HHS R01 HL119012NHLBI NIH HHS R35 HL135827NHLBI NIH HHS T32 HL007227NIAID NIH HHS R01 AI077610NIAID NIH HHS R01 AI091481
Abstract
The mechanistic target of rapamycin complex-1 (mTORC1) coordinates regulation of growth, metabolism, protein synthesis and autophagy
Indexed as
AnimalsAutophagyCells, CulturedCyclic GMP-Dependent Protein KinasesDisease ProgressionEnzyme ActivationEverolimusFemaleGene Knock-In TechniquesHeart DiseasesHEK293 CellsHumansHypertrophyMaleMechanistic Target of Rapamycin Complex 1MiceCyclic GMP-Dependent Protein KinasesEverolimusMechanistic Target of Rapamycin Complex 1PhosphoserineSerineTSC2 protein, humanTuberous Sclerosis Complex 2 Protein
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.