Evidence map›Paper›PMID 30701360›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Influence of methionine-ruthenium complex on the fibril formation of human islet amyloid polypeptide.

Gehui Gong, Jufei Xu, Xiangyi Huang, Weihong Du

Open access · bronzeAbstract read

PubMed Publisher

In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

2.2field-weighted citation impact, top 12% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

Human islet amyloid polypeptide: A therapeutic target for the management of type 2 diabetes mellitus.Journal of pharmaceutical analysis · 2022
Review
Glucosyl Platinum(II) Complexes Inhibit Aggregation of the C-Terminal Region of the Aβ Peptide.Inorganic chemistry · 2022
Article
Modulation of Amyloidogenic Peptide Aggregation by Photoactivatable CO-Releasing Ruthenium(II) Complexes.Pharmaceuticals (Basel, Switzerland) · 2020
Article
An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
Article
The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design.PloS one · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gehui GongDepartment of Chemistry, Renmin University of China, Beijing, 100872, China.

Jufei XuDepartment of Chemistry, Renmin University of China, Beijing, 100872, China.

Xiangyi HuangDepartment of Chemistry, Renmin University of China, Beijing, 100872, China.

Weihong DuDepartment of Chemistry, Renmin University of China, Beijing, 100872, China. whdu@ruc.edu.cn.

Renmin University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abnormal aggregation and deposition of human islet amyloid polypeptide (hIAPP) are implicated in the pathogeny of type 2 diabetes mellitus (T2DM). Many aromatic ring-containing Ru complexes inhibit the aggregation of hIAPP. A new Ru complex Ru(bipy)(met)

Indexed as

AnimalsCells, CulturedCoordination ComplexesHumansIslet Amyloid PolypeptideMethionineMolecular StructureParticle SizeRatsRutheniumSurface PropertiesCoordination ComplexesIslet Amyloid PolypeptideMethionineRutheniumFibril formationhIAPPInhibitionRuthenium complexes

Identifiers

PMID30701360

DOI10.1007/s00775-019-01637-6

OpenAlexW2913218002

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.