Evidence map›Paper›PMID 30701611›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Pilot study on longitudinal change in pancreatic proton density fat fraction during a weight-loss surgery program in adults with obesity.

Yesenia Covarrubias, Kathryn J Fowler, Adrija Mamidipalli, Gavin Hamilton, Tanya Wolfson, Olof Dahlqvist Leinhard, Garth Jacobsen, Santiago Horgan, Jeffrey B Schwimmer, Scott B Reeder and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Intra-pancreatic fat deposition: bringing hidden fat to the fore.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  9. Proton density fat fraction: magnetic resonance imaging applications beyond the liver.Diagnostic and interventional radiology (Ankara, Turkey) · 2022
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Yesenia CovarrubiasLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, La Jolla, California, USA.
Kathryn J FowlerLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, La Jolla, California, USA.
Adrija MamidipalliLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, La Jolla, California, USA.
Gavin HamiltonLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, La Jolla, California, USA.
Tanya WolfsonComputational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California, San Diego, La Jolla, California, USA.
Olof Dahlqvist LeinhardAMRA Medical AB, Linköping, Sweden.
Garth JacobsenDepartment of Surgery, University of California, San Diego, La Jolla, California, USA.
Santiago HorganDepartment of Surgery, University of California, San Diego, La Jolla, California, USA.
Jeffrey B SchwimmerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Scott B ReederDepartment of Radiology, University of Wisconsin - Madison, Madison, Wisconsin, USA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, La Jolla, California, USA.
University of California, San Diego · USUniversity of California System · USLinköping University · SERady Children's Hospital-San Diego · USSan Diego Supercomputer Center · USUniversity of Wisconsin–Madison · US

Funding

NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK100651
6 · The paper itself

Abstract

backgroundQuantitative-chemical-shift-encoded (CSE)-MRI methods have been applied to the liver. The feasibility and potential utility CSE-MRI in monitoring changes in pancreatic proton density fat fraction (PDFF) have not yet been demonstrated. PURPOSE: To use quantitative CSE-MRI to estimate pancreatic fat changes during a weight-loss program in adults with severe obesity and nonalcoholic fatty liver disease (NAFLD). To explore the relationship of reduction in pancreatic PDFF with reductions in anthropometric indices. STUDY TYPE: Prospective/longitudinal. POPULATION: Nine adults with severe obesity and NAFLD enrolled in a weight-loss program. FIELD STRENGTH/SEQUENCE: CSE-MRI fat quantification techniques and multistation-volumetric fat/water separation techniques were performed at 3 T. ASSESSMENT: PDFF values were recorded from parametric maps colocalized across timepoints. STATISTICAL TESTS: Rates of change of log-transformed variables across time were determined (linear-regression), and their significance assessed compared with no change (Wilcoxon test). Rates of change were correlated pairwise (Spearman's correlation).

resultsMean pancreatic PDFF decreased by 5.7% (range 0.7-17.7%) from 14.3 to 8.6%, hepatic PDFF by 11.4% (2.6-22.0%) from 14.8 to 3.4%, weight by 30.9 kg (17.3-64.2 kg) from 119.0 to 88.1 kg, body mass index by 11.0 kg/m DATA

conclusionChanges in pancreatic PDFF can be estimated by quantitative CSE-MRI in adults undergoing a weight-loss surgery program. Pancreatic and hepatic PDFF and anthropometric indices decreased significantly. LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1092-1102.

Indexed as

Bariatric SurgeryAdipose TissueAdultAgedFemaleHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedObesity, MorbidPancreasPilot ProjectsProspective StudiesWeight Reduction Programslongitudinal changepancreatic PDFFproton density fat fractionquantitative CSE-MRIweight-loss surgery (WLS) program

Identifiers

PMID30701611
PMCPMC6667307
OpenAlexW2914009490

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.