Evidence map›Paper›PMID 30705188›Full record

ArticleScience (New York, N.Y.)2019

A sleep-inducing gene,

Hirofumi Toda, Julie A Williams, Michael Gulledge, Amita Sehgal

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed.

  1. A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
  4. Regulation of Metabolic Rhythms by Glial Clocks.Journal of biological rhythms · 2026
    Article
  5. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  6. The use ofFrontiers in cell and developmental biology · 2026
    Review
  7. Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Antimicrobial peptides: from discovery to developmental applications.Applied and environmental microbiology · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Michael GulledgeHoward Hughes Medical Institute, Chronobiology Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5910-7898

Funding

Mechanisms of Cellular Stress-Induced SleepR01GM123783 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI NAIDOO, NIRMALA NIRINJINI, WILLIAMS, JULIE A · 2016 to 2019
$1.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM123783
6 · The paper itself

Abstract

Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for the drive to sleep. In an unbiased screen of more than 12,000

Indexed as

Immune SystemAnimalsAntimicrobial Cationic PeptidesArousalBacterial InfectionsBrainDrosophila melanogasterDrosophila ProteinsFemaleGain of Function MutationGene Knockout TechniquesHomeostasisMaleNeuronsSleepAntimicrobial Cationic PeptidesDrosophila Proteins

Identifiers

PMID30705188
PMCPMC6505470

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.