Evidence map›Paper›PMID 30715621›Full record

ArticleClinical oral investigations2019

Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw.

Mohammad Zandi, Arash Dehghan, Payam Amini, Shideh Doulati, Leila Rezaeian

Registry-linked trialAbstract read
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In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06061354 (Bone Microarchitecture and Implant Stabilization in Atrophic Jaws Reconstructed With Bone Grafts Treated With Teriparatide), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06061354 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Bone Microarchitecture and Implant Stabilization in Atrophic Jaws Reconstructed With Bone Grafts Treated With Teriparatide

TypeinterventionalSponsorUniversidad de ValparaisoRan2023 to 2024Enrolled42ConditionsBone RegenerationArmsTeriparatide, Maxillary Sinus Augmentation, Dental Implant Installation, Bone graft
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mohammad ZandiDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran. zandi88m@yahoo.com.
Arash DehghanDepartment of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.
Payam AminiDepartment of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Shideh DoulatiDepartment of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran.
Leila RezaeianDepartment of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran.
Hamedan University of Medical Sciences · IRAcademic Center for Education, Culture and Research · IR

Funding

Hamedan University of Medical Sciences 9507134134
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND

methodsTo induce MRONJ, a total of 120 rats received intravenous zoledronate 0.06 mg/kg once a week for 6 weeks and their right mandibular first molar was extracted. Eighty of 94 rats with MRONJ were randomly selected and underwent unilateral mandibular osteotomy to replicate a fracture. After surgery, the rats were randomly assigned to T (teriparatide-treated) and C (control) groups. Group T (n = 40) received subcutaneous injection of 2 μg/kg/day teriparatide and group C (n = 40) received the same volume of normal saline until sacrifice. Four and 8 weeks after surgery, 20 rats in each group were sacrificed. Fracture healing was scored using a histological grading system (1 to 10).

resultsIn group C, at 4 weeks and 8 weeks post-fracture, fibrous and cartilaginous tissues and scant bone formation at the fracture site and lacunae without osteocyte in adjacent mandibular bone were seen. In group T, substantial amounts of new trabecular bone rimmed by osteoblasts and some areas of remodeled mature bone were seen. After 8 weeks, extensive replacement of trabecular bone with mature bone occurred. Except between C4 and C8 groups, the healing score was significantly different between all subgroups.

conclusionTeriparatide therapy successfully improved mandibular fracture healing in rats with MRONJ. However, this study was limited by the use of an animal model whose anatomy, physiology, and drug metabolism might be different from humans. CLINICAL RELEVANCE: The present study showed that teriparatide therapy may be used adjunctive to surgery in the treatment of mandibular fractures in MRONJ patients.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsMandibular FracturesTeriparatideAnimalsFracture HealingRatsBone Density Conservation AgentsTeriparatideHealingMandibular fractureOsteonecrosisRatTeriparatide

Identifiers

PMID30715621
OpenAlexW2913799976

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.