Evidence map›Paper›PMID 30715654›Full record

ReviewClinical & experimental metastasis2019

Pressurized intraperitoneal aerosol chemotherapy and its effect on gastric-cancer-derived peritoneal metastases: an overview.

Miguel Alberto, Andreas Brandl, Pankaj Kumar Garg, Safak Gül-Klein, Mathias Dahlmann, Ulrike Stein, Beate Rau

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & experimental metastasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Molecular biology and immunology of gastric cancer peritoneal metastasis.Translational gastroenterology and hepatology · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miguel AlbertoDepartment of Surgery, Campus Virchow Klinikum - Campus Mitte, Charité - University Hospital Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Andreas BrandlDepartment of Surgery, Campus Virchow Klinikum - Campus Mitte, Charité - University Hospital Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Pankaj Kumar GargDepartment of Surgery, Guru Teg Bahadur Hospital, University College of Medical Sciences, University of Delhi, Delhi, India.
Safak Gül-KleinDepartment of Surgery, Campus Virchow Klinikum - Campus Mitte, Charité - University Hospital Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Mathias DahlmannTranslational Oncology of Solid Tumors, Experimental and Clinical Research Center, Charité University Hospital Berlin, Berlin, Germany.
Ulrike SteinTranslational Oncology of Solid Tumors, Experimental and Clinical Research Center, Charité University Hospital Berlin, Berlin, Germany.
Beate RauDepartment of Surgery, Campus Virchow Klinikum - Campus Mitte, Charité - University Hospital Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. beate.rau@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This manuscript aspires to portray a review of the current literature focusing on manifest peritoneal metastasis (PM) derived from gastric cancer and its treatment options. Despite the development of chemotherapy and multimodal treatment options during the last decades, mortality remains high worldwide. After refreshing important epidemiological considerations, the molecular mechanisms currently accepted through which PM occurs are revised. Palliative chemotherapy is the only recommended treatment option for patients with PM of gastric cancer according to the National Comprehensive Cancer Network guidelines, although cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy demonstrated promising results in selected patients with regional PM and localized intraabdominal tumor spread. A novel treatment named pressurized intraperitoneal aerosol chemotherapy may have a promising future in improving overall survival with an acceptable postoperative complication rate and stabilizing quality of life during treatment. Additionally, the procedure has been proved to be safe for the patient and medical personnel and a feasible, repeatable method to deter metastatic proliferation. This overview comprehensively addresses this novel and promising treatment in the context of a scientifically and clinically challenging disease.

Indexed as

Drug Delivery SystemsAerosolsAntineoplastic Combined Chemotherapy ProtocolsHumansPeritoneal NeoplasmsPressureStomach NeoplasmsAerosolsGastric cancerHyperthermic Intraperitoneal ChemotherapyIntraperitoneal chemotherapyMolecular mechanisms of peritoneal metastasisPeritoneal metastasesPressurized intraperitoneal aerosol chemotherapy

Identifiers

PMID30715654

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.