Evidence mapPaperPMID 30718964Full record

ReviewBreast cancer (Dove Medical Press)2019

Overview of the genetic basis toward early detection of breast cancer.

Sumadee De Silva, Kamani Hemamala Tennekoon, Eric Hamilton Karunanayake

Abstract readReview
In one paragraph

Review in Breast cancer (Dove Medical Press), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  20. Genetically Engineered Pigs to Study Cancer.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sumadee De SilvaInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka, sum@ibmbb.cmb.ac.lk.
Kamani Hemamala TennekoonInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka, sum@ibmbb.cmb.ac.lk.
Eric Hamilton KarunanayakeInstitute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka, sum@ibmbb.cmb.ac.lk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. In this review, it was aimed to discuss the characteristics of cancer genome, cancer genetics, and cancer epigenetics in general and then focus on discussing both genetic and nongenetic factors responsible for the predisposition of breast cancer in humans. More emphasis was placed on genes responsible for the early onset of the disease and which can be used as genetic tools in the identification of the disease at an early stage. Then the context of genetic involvement toward the breast cancer occurrence before age of 40 years was highlighted accordingly. In addition to genetic testing, the review paid adequate attention to mention novel liquid biopsy techniques and other clinical, laboratory, and radiologic assessments. These techniques can be used in early detection and recurrence as well as the surveillance of the patients after primary therapies.

Indexed as

breast cancerearly onsetgenetic predispositionrecurrence

Identifiers

PMID30718964
PMCPMC6345186

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.