Evidence map›Paper›PMID 30723843›Full record

ReviewBioactive materials2019

Review: Bioengineering approach for the repair and regeneration of peripheral nerve.

Joshua Moskow, Bryan Ferrigno, Nikhil Mistry, Devina Jaiswal, Ketan Bulsara, Swetha Rudraiah, Sangamesh G Kumbar

Erratum issuedAbstract readReview
In one paragraph

Review in Bioactive materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Materials today. Bio · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Joshua MoskowDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.
Bryan FerrignoDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.
Nikhil MistryDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.
Devina JaiswalDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.
Ketan BulsaraDepartment of Surgery, University of Connecticut Health, 263 Farmington Ave., Farmington, CT 06030, USA.
Swetha RudraiahDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.
Sangamesh G KumbarDepartment of Orthopaedic Surgery, University of Connecticut Health, 263Farmington Ave., Farmington, CT 06030, USA.

Funding

Targeting PHLPP to treat interval disc degeneration using surgical and drug delivery methodsR01AR078908 · NIAMS · EMORY UNIVERSITY · PI Svenja Illien-Junger · 2022 to 2026
$1.9M
Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Polysaccharide putty formulations for tissue regenerationR01EB034202 · NIBIB · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2023 to 2026
$1.5M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
Supplement to Support the Acquisition of a High-Precision 3D PrinterR01NS134604 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2024 to 2026
$1.3M
Engineered Matrices with Electrical and Chemical Stimulation for Peripheral Nerve RepairR56NS122753 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA · 2022 to 2022
$410k
NIAMS NIH HHS R01 AR078908NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060NIBIB NIH HHS R01 EB034202NINDS NIH HHS R01 NS134604NINDS NIH HHS R56 NS122753
6 · The paper itself

Abstract

Complex craniofacial surgeries of damaged tissues have several limitations, which present complications and challenges when trying to replicate facial function and structure. Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks. As technology continues to advance, new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure. This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds, bioactive factors, and external stimuli alone or in combination to support peripheral nerve regeneration. Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process.

Indexed as

Composite materialsElectrical stimulationGrowth factorPeripheral nerve regeneration

Identifiers

PMID30723843
PMCPMC6351356

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.