ArticleHippocampus2019
Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization.
Article in Hippocampus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Article
- Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality.Biomolecules · 2026Review
- The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dopamine D4 Receptor Agonist Drastically Increases Delta Activity in the Thalamic Nucleus Reuniens: Potential Role in Communication between Prefrontal Cortex and Hippocampus.International journal of molecular sciences · 2023Article
- Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations.eLife · 2023Article
- Development of network oscillations through adolescence in male and female rats.Frontiers in cellular neuroscience · 2023Article
- Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019.Frontiers in neuroscience · 2023Article
- Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.Molecular autism · 2022Article
- Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?Heliyon · 2022Review
- Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders.International journal of molecular sciences · 2022Review
- Article
- Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype.Scientific reports · 2022Article
- The shallow cognitive map hypothesis: A hippocampal framework for thought disorder in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Review
- A Perspective on the Potential Involvement of Impaired Proteostasis in Neuropsychiatric Disorders.Biological psychiatry · 2022Review
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
- Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice.Brain and behavior · 2020Article
- Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia.Brain : a journal of neurology · 2020Article
- Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization.Hippocampus · 2019Article
- Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.Translational psychiatry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Aberrant proteostasis of protein aggregation may lead to behavior disorders including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations that underlie CMI are not well understood. We recorded the local field potential and single-unit activity of the hippocampal CA1 region in vivo in rats transgenically overexpressing the Disrupted-in-Schizophrenia 1 (DISC1) gene (tgDISC1), modeling sporadic CMI. These tgDISC1 rats have previously been shown to exhibit DISC1 protein aggregation, disturbances in the dopaminergic system and attention-related deficits. Recordings were performed during exploration of familiar and novel open field environments and during sleep, allowing investigation of neuronal abnormalities in unconstrained behavior. Compared to controls, tgDISC1 place cells exhibited smaller place fields and decreased speed-modulation of their firing rates, demonstrating altered spatial coding and deficits in encoding location-independent sensory inputs. Oscillation analyses showed that tgDISC1 pyramidal neurons had higher theta phase locking strength during novelty, limiting their phase coding ability. However, their mean theta phases were more variable at the population level, reducing oscillatory network synchronization. Finally, tgDISC1 pyramidal neurons showed a lack of novelty-induced shift in their preferred theta and gamma firing phases, indicating deficits in coding of novel environments with oscillatory firing. By combining single cell and neuronal population analyses, we link DISC1 protein pathology with abnormal hippocampal neural coding and network synchrony, and thereby gain a more comprehensive understanding of CMI mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.