Evidence map›Paper›PMID 30726205›Full record

ArticlePLoS computational biology2019

Apollo: Democratizing genome annotation.

Nathan A Dunn, Deepak R Unni, Colin Diesh, Monica Munoz-Torres, Nomi L Harris, Eric Yao, Helena Rasche, Ian H Holmes, Christine G Elsik, Suzanna E Lewis

Abstract read
In one paragraph

Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed.

  1. Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  4. The complete genome sequence ofMicrobiology resource announcements · 2026
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  5. Review
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  7. Review
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  10. Article
  11. Article
  12. Article
  13. Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Frontiers in plant science · 2026
    Article
  16. Article
  17. Organelle genome architecture ofFrontiers in plant science · 2026
    Article
  18. The complete chloroplast genome and phylogenetic analysis ofMitochondrial DNA. Part B, Resources · 2026
    Article
  19. Article
  20. MedakaBase as a unified genomic resource platform for medaka fish biology.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025
    Article

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nathan A DunnEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.ORCID 0000-0002-4862-3181
Deepak R UnniEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.ORCID 0000-0002-3583-7340
Colin DieshDeptartment of Bioengineering, University of California, Berkeley, California, United States of America.
Monica Munoz-TorresTranslational and Integrative Sciences Lab, Oregon State University, Corvallis, Oregon, United States of America.ORCID 0000-0001-8430-6039
Nomi L HarrisEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.ORCID 0000-0001-6315-3707
Eric YaoDeptartment of Bioengineering, University of California, Berkeley, California, United States of America.ORCID 0000-0002-1472-1832
Helena RascheBioinformatics Group, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-9760-8992
Ian H HolmesDeptartment of Bioengineering, University of California, Berkeley, California, United States of America.
Christine G ElsikAnimal Sciences Division, University of Missouri, Columbia, Missouri, United States of America.ORCID 0000-0002-4248-7713
Suzanna E LewisEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.

Funding

Novel Web-based Tools for Collaborative Community-Driven Genome Feature AnnotatioR01GM080203 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ian H Holmes · 2007 to 2026
$8.5M
NIGMS NIH HHS R01 GM080203
6 · The paper itself

Abstract

Genome annotation is the process of identifying the location and function of a genome's encoded features. Improving the biological accuracy of annotation is a complex and iterative process requiring researchers to review and incorporate multiple sources of information such as transcriptome alignments, predictive models based on sequence profiles, and comparisons to features found in related organisms. Because rapidly decreasing costs are enabling an ever-growing number of scientists to incorporate sequencing as a routine laboratory technique, there is widespread demand for tools that can assist in the deliberative analytical review of genomic information. To this end, we present Apollo, an open source software package that enables researchers to efficiently inspect and refine the precise structure and role of genomic features in a graphical browser-based platform. Some of Apollo's newer user interface features include support for real-time collaboration, allowing distributed users to simultaneously edit the same encoded features while also instantly seeing the updates made by other researchers on the same region in a manner similar to Google Docs. Its technical architecture enables Apollo to be integrated into multiple existing genomic analysis pipelines and heterogeneous laboratory workflow platforms. Finally, we consider the implications that Apollo and related applications may have on how the results of genome research are published and made accessible.

Indexed as

Chromosome MappingComputational BiologyDatabase Management SystemsGenomeGenomicsInformation Storage and RetrievalInternetMolecular Sequence AnnotationSoftwareUser-Computer Interface

Identifiers

PMID30726205
PMCPMC6380598

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.