Evidence map›Paper›PMID 30727807›Full record

ArticleThe Journal of international medical research2019

Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.

Zhanrong Qiang, Lingyu Meng, Caixia Yi, Lianying Yu, Wenxia Chen, Weihong Sha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 69 citations in OpenAlex.

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  10. Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zhanrong Qiang1 Southern Medical University, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0001-8656-2087
Lingyu Meng3 Department of Gastroenterology and Hepatology, the Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Province, China.
Caixia Yi4 Guilin Medical University, Guilin, Guangxi Province, China.
Lianying Yu1 Southern Medical University, Guangzhou, Guangdong Province, China.
Wenxia Chen1 Southern Medical University, Guangzhou, Guangdong Province, China.
Weihong Sha1 Southern Medical University, Guangzhou, Guangdong Province, China.
Guangdong General Hospital · CNGuilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePD98059 is a potent and selective inhibitor of mitogen-activated protein kinase. Substantial preclinical evidence has shown an anti-tumor effect of curcumin on various solid tumors. This study aimed to investigate whether curcumin synergistically acts with PD98059 in exerting anti-gastric cancer effects.

methodsThe cell counting kit-8 assay was used to detect cell proliferation of the human gastric cancer MGC-803 cell line. Flow cytometry was performed to detect apoptosis. Western blotting was used to detect phosphatase and tensin homolog (PTEN) and phosphorylated Akt (p-Akt) expression levels. Quantitative reverse transcription-polymerase chain reaction was used to determine microRNA-21 (miR-21).

resultsA dose of 5 to 40 µM curcumin inhibited proliferation of MGC-803 cells in a dose- and time-dependent manner. A high dose of curcumin strongly inhibited p-Akt protein expression. With increasing curcumin levels, PTEN expression increased and miR-21 levels decreased. These results suggest that curcumin negatively modulated the miR-21/PTEN/Akt pathway. Moreover, after pretreatment with PD98059, cell apoptosis induced by curcumin was significantly increased. Additionally, the inhibitory effects of curcumin on the miR-21/PTEN/Akt pathway were significantly enhanced.

conclusionPD98059 combined with curcumin may be a potential strategy for managing gastric cancer.

Indexed as

Drug SynergismAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCell ProliferationCurcuminFlavonoidsGene Expression Regulation, NeoplasticHumansMicroRNAsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseStomach NeoplasmsTumor Cells, Cultured2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneAKT1 protein, humanAntineoplastic AgentsCurcuminFlavonoidsMicroRNAsMIRN21 microRNA, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanapoptosisCurcuminmicroRNA-21 (miR-21)mitogen-activated protein kinase (MAPK) inhibitorphosphatase and tensin homolog (PTEN)stomach neoplasm

Identifiers

PMID30727807
PMCPMC6421392
OpenAlexW2912508713

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.