Evidence map›Paper›PMID 30727936›Full record

ArticleEndocrine, metabolic & immune disorders drug targets2019

Metabolic Association between Leptin and the Corticotropin Releasing Hormone.

Sofia Gioldasi, Alexia Karvela, Andrea Paola Rojas-Gil, Maria Rodi, Anne-Lise de Lastic, Iason Thomas, Bessie E Spiliotis, Athanasia Mouzaki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, metabolic & immune disorders drug targets, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sofia GioldasiDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Alexia KarvelaDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Medical School, University of Patras, Patras, Greece.
Andrea Paola Rojas-GilDepartment of Nursing, University of Peloponnese, Sparta, Greece.
Maria RodiDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Anne-Lise de LasticDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Iason ThomasDepartment of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Bessie E SpiliotisDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Medical School, University of Patras, Patras, Greece.
Athanasia MouzakiDivision of Hematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
University of Patras · GRGuy's and St Thomas' NHS Foundation Trust · GBUniversity of Peloponnese · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn healthy individuals, leptin is produced from adipose tissue and is secreted into the circulation to communicate energy balance status to the brain and control fat metabolism. Corticotropin- Releasing Hormone (CRH) is synthesized in the hypothalamus and regulates stress responses. Among the many adipokines and hormones that control fat metabolism, leptin and CRH both curb appetite and inhibit food intake. Despite numerous reports on leptin and CRH properties and function, little has been actually shown about their association in the adipose tissue environment.

methodsIn this article, we summarized the salient information on leptin and CRH in relation to metabolism. We also investigated the direct effect of recombinant CRH on leptin secretion by primary cultures of human adipocytes isolated from subcutaneous abdominal adipose tissue of 7 healthy children and adolescents, and measured CRH and leptin levels in plasma collected from peripheral blood of 24 healthy children and adolescents to assess whether a correlation exists between CRH and leptin levels in the periphery. RESULTS AND

conclusionThe available data indicate that CRH exerts a role in the regulation of leptin in human adipocytes. We show that CRH downregulates leptin production by mature adipocytes and that a strong negative correlation exists between CRH and leptin levels in the periphery, and suggest the possible mechanisms of CRH control of leptin. Delineation of CRH control of leptin production by adipocytes may explain unknown pathogenic mechanisms linking stress and metabolism.

Indexed as

AdipocytesAdolescentCells, CulturedChildCorticotropin-Releasing HormoneEnergy MetabolismHumansLeptinCorticotropin-Releasing HormoneLeptinadipocytescorticotropin-releasing hormone (CRH)expressionLeptinmetabolismsignalingstress.

Identifiers

PMID30727936
PMCPMC7360915
OpenAlexW2912296795

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.