Evidence map›Paper›PMID 30728822›Full record

ArticleFrontiers in immunology2019

Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells.

Lucia Schnack, Yahya Sohrabi, Sina M M Lagache, Florian Kahles, Dennis Bruemmer, Johannes Waltenberger, Hannes M Findeisen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Review of OxLDL Driven Inflammatory Cell Activation.Current atherosclerosis reports · 2025
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Maladaptive trained immunity in viral infections.The Journal of clinical investigation · 2025
    Review
  8. Trained Immunity Induced by Oxidized Low-Density Lipoprotein Is Dependent on Glutaminolysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  9. Review
  10. Review
  11. The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lucia SchnackDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Yahya SohrabiDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Sina M M LagacheDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Florian KahlesDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Aachen, Germany.
Dennis BruemmerDivision of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Johannes WaltenbergerMedical Faculty, University of Münster, Münster, Germany.
Hannes M FindeisenDepartment of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
University Hospital Münster · DEUniversitätsklinikum Aachen · DEUniversity of Münster · DEUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunity, InnateBCG VaccineBiomarkersCoronary VesselsCytokinesGene ExpressionGlucoseHumansInflammation MediatorsLactic AcidLipoproteins, LDLMacrophagesMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionToll-Like Receptor 2BCG VaccineBiomarkersCytokinesGlucoseInflammation MediatorsLactic AcidLipoproteins, LDLoxidized low density lipoproteinTLR2 protein, humanToll-Like Receptor 2Toll-Like Receptor 4TOR Serine-Threonine KinasesinflammationmTORoxLDLsmooth muscle cellstrained innate immunity

Identifiers

PMID30728822
PMCPMC6351498
OpenAlexW2911340578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.