Evidence map›Paper›PMID 30737277›Full record

ArticleThe Journal of biological chemistry2019

Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ.

Ryan N Serio, Kristian B Laursen, Alison M Urvalek, Steven S Gross, Lorraine J Gudas

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells.International journal of molecular sciences · 2023
    Article
  5. Review
  6. Retinoid metabolism: new insights.Journal of molecular endocrinology · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Environmental mechanisms of orofacial clefts.Birth defects research · 2020
    Review
  13. Review
  14. Article
  15. Effects of environmental stressors on stem cells.World journal of stem cells · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ryan N SerioFrom the Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York 10065 and.
Kristian B LaursenDepartment of Pharmacology, Weill Cornell Medical College, New York, New York 10065.
Alison M UrvalekDepartment of Pharmacology, Weill Cornell Medical College, New York, New York 10065.
Steven S GrossFrom the Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York 10065 and.
Lorraine J GudasFrom the Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York 10065 and ljgudas@med.cornell.edu.ORCID 0000-0003-3115-4777
Cornell University · US

Funding

Risk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI GROSS, STEVEN S · 2011 to 2020
$12.6M
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1M
Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis ModelR01AA018332 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUDAS, LORRAINE J · 2010 to 2014
$2.1M
Alcohol-Induced Epigenetic Changes in Stem CellsR21AA021484 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUDAS, LORRAINE J · 2012 to 2013
$430k
Ethanol Metabolism in Embryonic Stem CellsF31AA024024 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SERIO, RYAN N · 2015 to 2018
$132k
NCI NIH HHS T32 CA062948NIAAA NIH HHS F31 AA024024NIAAA NIH HHS R01 AA018332NIAAA NIH HHS R21 AA021484NICHD NIH HHS P01 HD067244
6 · The paper itself

Abstract

Ethanol (EtOH) is a teratogen, but its teratogenic mechanisms are not fully understood. The alcohol form of vitamin A (retinol/ROL) can be oxidized to all-

Indexed as

Aldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAnimalsCell DifferentiationEthanolHomeobox A1 ProteinHomeodomain ProteinsMembrane ProteinsMiceMice, KnockoutMouse Embryonic Stem CellsReceptors, Retinoic AcidRetinal DehydrogenaseRetinoic Acid 4-HydroxylaseRetinoic Acid Receptor gammaSignal TransductionAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldh1a2 protein, mouseCyp26a1 protein, mouseEthanolHomeobox A1 ProteinHomeodomain ProteinsMembrane ProteinsReceptors, Retinoic AcidRetinal DehydrogenaseRetinoic Acid 4-HydroxylaseRetinoic Acid Receptor gammaStra6 protein, mouseTranscription Factorsalcoholalcohol-associated birth defectsdifferentiationethanolRARγRdh10retinoic acidretinolstem cellsStra6teratogen

Identifiers

PMID30737277
PMCPMC6462535
OpenAlexW2913248556

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.