Evidence map›Paper›PMID 30738041›Full record

ArticleJournal of immunological methods2019

A monoclonal antibody targeted to the functional peptide of αB-crystallin inhibits the chaperone and anti-apoptotic activities.

Rooban B Nahomi, Sandip K Nandi, Ram H Nagaraj

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunological methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rooban B NahomiSue Anschutz-Rodgers Eye Center and Department of Ophthalmology, University of Colorado School of Medicine, United States.
Sandip K NandiSue Anschutz-Rodgers Eye Center and Department of Ophthalmology, University of Colorado School of Medicine, United States.
Ram H NagarajSue Anschutz-Rodgers Eye Center and Department of Ophthalmology, University of Colorado School of Medicine, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, Aurora, CO 80045, United States. Electronic address: ram.nagaraj@ucdenver.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Molecular Mechanisms of Protein Crosslinking in the LensR01EY023286 · NEI · UNIVERSITY OF COLORADO DENVER · PI NAGARAJ, RAM H · 2013 to 2022
$2.9M
LENS CAPSULE AND SECONDARY CATARACTR01EY022061 · NEI · UNIVERSITY OF COLORADO DENVER · PI NAGARAJ, RAM H · 2013 to 2017
$1.9M
Acylation of Lens ProteinsR01EY028836 · NEI · UNIVERSITY OF COLORADO DENVER · PI NAGARAJ, RAM H · 2018 to 2021
$1.6M
NEI NIH HHS R01 EY022061NEI NIH HHS R01 EY023286NEI NIH HHS R01 EY028836
6 · The paper itself

Abstract

αB-Crystallin is a member of the small heat shock protein family. It is a molecular chaperone and an anti-apoptotic protein. Previous studies have shown that the peptide (

Indexed as

alpha-Crystallin B ChainAnimalsAntibodies, MonoclonalApoptosisMiceMice, Inbred BALB Calpha-Crystallin B ChainAntibodies, MonoclonalApoptosisChaperone activityMonoclonal antibodyPeptain-1αB-crystallin

Identifiers

PMID30738041
PMCPMC6677275
OpenAlexW2913270241

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.