Evidence map›Paper›PMID 30738358›Full record

ArticleThe Journal of surgical research2019

Leptinemia is Associated With Peripheral Artery Disease.

Greg J Zahner, Joel L Ramirez, Kimberly A Spaulding, Sukaynah A Khetani, Warren J Gasper, Carl Grunfeld, Nancy K Hills, Anne L Schafer, S Marlene Grenon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Obesity and cardiovascular disease in women.International journal of obesity (2005) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Greg J ZahnerDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Joel L RamirezDepartment of Surgery, University of California, San Francisco, San Francisco, California.
Kimberly A SpauldingDepartment of Surgery, University of California, San Francisco, San Francisco, California; Vascular Surgery Section, Veterans Affairs Medical Center, San Francisco, California.
Sukaynah A KhetaniDepartment of Surgery, University of California, San Francisco, San Francisco, California; Vascular Surgery Section, Veterans Affairs Medical Center, San Francisco, California.
Warren J GasperDepartment of Surgery, University of California, San Francisco, San Francisco, California; Vascular Surgery Section, Veterans Affairs Medical Center, San Francisco, California.
Carl GrunfeldDepartment of Medicine, University of California, San Francisco, San Francisco, California; Metabolism Section, Veterans Affairs Medical Center, San Francisco, California.
Nancy K HillsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Anne L SchaferDepartment of Medicine, University of California, San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California; Endocrine Research Unit, Veterans Affairs Medical Center, San Francisco, California.
S Marlene GrenonDepartment of Surgery, University of California, San Francisco, San Francisco, California. Electronic address: marlene.grenon@ucsf.edu.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SUNEIL Krishna KOLIWAD · 2015 to 2026
$14.6M
NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
Effects of fish oil on inflammation and vascular function in claudicantsK23HL122446 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRENON, MARLENE · 2014 to 2017
$806k
NCATS NIH HHS TL1 TR001871NCRR NIH HHS KL2 RR024130NHLBI NIH HHS K23 HL122446NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

backgroundLeptin, adiponectin, and resistin are in a class of hormones called adipokines that are produced by adipocytes and have been implicated in the causal pathway of atherosclerosis. We examined the association between adipokine levels and peripheral artery disease (PAD), hypothesizing that after adjusting for fat mass, leptin and resistin would be higher, whereas adiponectin would be lower, in patients with PAD.

methodsA cross-sectional sample of 179 predominately male (97%) vascular surgery outpatients was recruited from the San Francisco Veterans Affairs Medical Center (SFVAMC). PAD was defined as either an ankle-brachial index < 0.9 plus symptoms of claudication or prior revascularization for symptomatic PAD (n = 141). Controls had an ankle-brachial index ≥0.9 and no history of atherosclerotic disease (n = 38). Adipokines were assayed using commercially available ELISA kits and values were log-transformed. Fat mass was measured using bioelectrical impedance.

resultsIn an analysis adjusting for body mass index (BMI) and atherosclerotic risk factors, higher serum leptin was associated with PAD (OR 2.54, 95% CI 1.07-6.01, P = 0.03), whereas high molecular weight adiponectin was inversely associated, though not significantly (OR 0.60, 95% CI 0.33-1.08, P = 0.09). Resistin was not associated with PAD. Sensitivity analyses using fat mass/height

conclusionsThese results indicate that after adjusting for BMI or fat mass, serum leptin levels are positively and independently associated with PAD, whereas high molecular weight adiponectin might be inversely associated. Using a more representative, nonveteran sample, further investigations should focus on the potential role of adipokines in the pathophysiology of PAD as well as determine whether leptin levels have clinical utility in predicting PAD outcomes.

Indexed as

AdiponectinAgedCross-Sectional StudiesFemaleHumansIntermittent ClaudicationLeptinMaleMiddle AgedOutpatient Clinics, HospitalPeripheral Arterial DiseaseUnited StatesUnited States Department of Veterans AffairsVeteransAdiponectinADIPOQ protein, humanLEP protein, humanLeptinAdipokinesAdiponectinLeptinPeripheral artery diseaseVascular biology

Identifiers

PMID30738358
PMCPMC6451889
OpenAlexW2913912277

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.