Evidence map›Paper›PMID 30738546›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019

Developmental Premorbid Body Mass Index Trajectories of Adolescents With Eating Disorders in a Longitudinal Population Cohort.

Zeynep Yilmaz, Nisha C Gottfredson, Stephanie C Zerwas, Cynthia M Bulik, Nadia Micali

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  8. Profile of maladaptive and normative eating behaviors in correlation with rumination: a cross-sectional study among Lebanese adults.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Zeynep YilmazUniversity of North Carolina at Chapel Hill.
Nisha C GottfredsonUniversity of North Carolina at Chapel Hill.
Stephanie C ZerwasUniversity of North Carolina at Chapel Hill.
Cynthia M BulikUniversity of North Carolina at Chapel Hill; Karolinska Institutet, Stockholm, Sweden.
Nadia MicaliIcahn School of Medicine at Mount Sinai, New York, NY; the University of Geneva, Switzerland; and the Institute of Child Health, University College London, UK. Electronic address: Nadia.Micali@hcuge.ch.
University of North Carolina at Chapel Hill · USUniversity of Geneva · CH

Funding

The Impact of Affect Regulatory Mechanisms and Binge Eating on Drug RecoveryK01DA035153 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOTTFREDSON O'SHEA, NISHA · 2014 to 2018
$777k
Shared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620k
Developmental Psychopathology of Restrictive and Binge Eating in ChildhoodK01MH100435 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZERWAS, STEPHANIE CHRISTINE · 2013 to 2015
$488k
Polygenic and trans-diagnostic risk for anorexia nervosa and obsessive-compulsive disorder: Novel associations with emotional, behavioral, and cognitive dysfunction in a population-based cohortR21MH109917 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MICALI, NADIA, ZERWAS, STEPHANIE CHRISTINE · 2016 to 2017
$454k
Premorbid metabolism and growth in anorexia nervosa: A genetically informed exploration of riskR21MH115397 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2017 to 2018
$362k
Department of Health DHCS/08/08/012Medical Research Council G9815508Medical Research Council MC_PC_19009Medical Research Council MR/R004803/1MRF_ MRF-058-0001-RG-MICALNIDA NIH HHS K01 DA035153NIMH NIH HHS K01 MH100435NIMH NIH HHS K01 MH109782NIMH NIH HHS R21 MH109917NIMH NIH HHS R21 MH115397Wellcome TrustWellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

objectiveTo examine whether childhood body mass index (BMI) trajectories are prospectively associated with later eating disorder (ED) diagnoses.

methodUsing a subsample from the Avon Longitudinal Study of Parents and Children (N = 1,502), random-coefficient growth models were used to compare premorbid BMI trajectories of individuals who later developed anorexia nervosa (n = 243), bulimia nervosa (n = 69), binge-eating disorder (n = 114), and purging disorder (n = 133) and a control group without EDs or ED symptoms (n = 966). BMI was tracked longitudinally from birth to 12.5 years of age and EDs were assessed at 14, 16, and 18 years of age.

resultsDistinct developmental trajectories emerged for EDs at a young age. The average growth trajectory for individuals with later anorexia nervosa veered significantly below that of the control group before 4 years of age for girls and 2 years for boys. BMI trajectories were higher than the control trajectory for all other ED groups. Specifically, the mean bulimia nervosa trajectory veered significantly above that of controls at 2 years for girls, but boys with later bulimia nervosa did not exhibit higher BMIs. The mean binge-eating disorder and purging disorder trajectories significantly diverged from the control trajectory at no older than 6 years for girls and boys.

conclusionPremorbid metabolic factors and weight could be relevant to the etiology of ED. In anorexia nervosa, premorbid low weight could represent a key biological risk factor or early manifestation of an emerging disease process. Observing children whose BMI trajectories persistently and significantly deviate from age norms for signs and symptoms of ED could assist the identification of high-risk individuals.

Indexed as

Body Mass IndexAdolescentBody WeightChildChild, PreschoolFeeding and Eating DisordersFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleRisk FactorsUnited KingdomAvon Longitudinal Study of Parents and Children (ALSPAC)developmenteating disorderspremorbid body mass indexprospective

Identifiers

PMID30738546
PMCPMC6766404
OpenAlexW2903612308

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.