Evidence map›Paper›PMID 30741318›Full record

SynthesisInternational urogynecology journal2019

Uterine-preserving surgeries for the repair of pelvic organ prolapse: a systematic review with meta-analysis and clinical practice guidelines.

Kate V Meriwether, Ethan M Balk, Danielle D Antosh, Cedric K Olivera, Shunaha Kim-Fine, Miles Murphy, Cara L Grimes, Ambereen Sleemi, Ruchira Singh, Alexis A Dieter and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urogynecology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 2 countries.

Kate V MeriwetherDepartment of Obstetrics and Gynecology, University of Louisville, 550 S. Jackson, Ambulatory Care Building, Louisville, KY, 40202, USA. kate.meriwether@louisville.edu.ORCID 0000-0003-1167-3772
Ethan M BalkCenter for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI, USA.
Danielle D AntoshDepartment of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, USA.
Cedric K OliveraDepartment of Obstetrics and Gynecology, New York University, New York, NY, USA.
Shunaha Kim-FineDepartment of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada.
Miles MurphyThe Institute for Female Pelvic Medicine & Reconstructive Surgery, North Wales, PA, USA.
Cara L GrimesDepartment of Obstetrics and Gynecology, New York Medical College, Valhalla, NY, USA.
Ambereen SleemiInternational Medical Response, Brooklyn, NY, USA.
Ruchira SinghDepartment of Obstetrics and Gynecology, University of Florida Health, Jacksonville, FL, USA.
Alexis A DieterDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.
Catrina C CrispDivision of Female Pelvic Medicine and Reconstructive Surgery, TriHealth, Cincinnati, OH, USA.
David D RahnDepartment of Obstetrics and Gynecology, University of Texas Southwestern, Dallas, TX, USA.
Institute for Female Pelvic Medicine and Reconstructive Surgery · USBrown University · USMethodist Hospital · USNew York Medical College · USNew York University · USResponse Technologies (United States) · USThe University of Texas Southwestern Medical Center · USUniversity of Calgary · CAUniversity of Florida Health · USUniversity of Louisville · USUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisWe aimed to systematically review the literature on pelvic organ prolapse (POP) surgery with uterine preservation (hysteropexy). We hypothesized that different hysteropexy surgeries would have similar POP outcomes but varying adverse event (AE) rates.

methodsMEDLINE, Cochrane, and clinicaltrials.gov databases were reviewed from inception to January 2018 for comparative (any size) and single-arm studies (n ≥ 50) involving hysteropexy. Studies were extracted for participant characteristics, interventions, comparators, outcomes, and AEs and assessed for methodological quality.

resultsWe identified 99 eligible studies: 53 comparing hysteropexy to POP surgery with hysterectomy, 42 single-arm studies on hysteropexy, and four studies comparing stage ≥2 hysteropexy types. Data on POP outcomes were heterogeneous and usually from <3 years of follow-up. Repeat surgery prevalence for POP after hysteropexy varied widely (0-29%) but was similar among hysteropexy types. When comparing sacrohysteropexy routes, the laparoscopic approach had lower recurrent prolapse symptoms [odds ratio (OR) 0.18, 95% confidence interval (CI) 0.07-0.46), urinary retention (OR 0.05, 95% CI 0.003-0.83), and blood loss (difference -104 ml, 95% CI -145 to -63 ml) than open sacrohysteropexy. Laparoscopic sacrohysteropexy had longer operative times than vaginal mesh hysteropexy (difference 119 min, 95% CI 102-136 min). Most commonly reported AEs included mesh exposure (0-39%), urinary retention (0-80%), and sexual dysfunction (0-48%).

conclusionsHysteropexies have a wide range of POP recurrence and AEs; little data exist directly comparing different hysteropexy types. Therefore, for women choosing uterine preservation, surgeons should counsel them on outcomes and risks particular to the specific hysteropexy type planned.

Indexed as

FemaleGynecologic Surgical ProceduresHumansHysterectomyOperative TimeOrgan Sparing TreatmentsPelvic Organ ProlapseRecurrenceReoperationSexual Dysfunction, PhysiologicalSurgical MeshUrinary RetentionUterusHysteropexyProlapseRisksSurgerySystematic reviewUterine preservation

Identifiers

PMID30741318
OpenAlexW2913151274

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.