ArticleJournal of thoracic disease2018
Hematological indices as simple, inexpensive and practical severity markers of obstructive sleep apnea syndrome: a meta-analysis.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome: A systemic review and meta-analysis.PloS one · 2024Pooled it
- Associations Between Anemia and Obstructive Sleep Apnea in Patients with Cystic and Non-Cystic Bronchiectasis: A Prospective Cross-Sectional Study.Biomedicines · 2026Article
- The association of complete blood count parameters and obstructive sleep apnea in the Cypriot population.Sleep & breathing = Schlaf & Atmung · 2025Article
- Usefulness of Blood Biomarkers in Screening Patients with Obstructive Sleep Apnea: Could Albumin Indices and Uric Acid-to-HDL Ratio Be New OSAS Severity Indices?Advances in respiratory medicine · 2025Article
- Role of hematological parameters and inflammatory indices in determining the severity of obstructive sleep apnea syndrome: reality or myth?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Impact of obstructive sleep apnea on hematocrit levels and erythrocytosis - a clinical study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Role of endothelial dysfunction in sleep-disordered breathing in egyptian children with sickle cell disease.BMC pediatrics · 2024Article
- Is there a relationship between the severity of obstructive sleep apnea syndrome and the systemic immune inflammation index?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Rapid eye movement dependency is associated with increased inflammatory activity in obstructive sleep apnea syndrome.Brain and behavior · 2024Article
- Sex-Specific Associations Between Leucocyte Measures and Obstructive Sleep Apnea in Han Chinese.Nature and science of sleep · 2024Article
- Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Evaluation of Inflammation and Oxidative Stress Markers in Patients with Obstructive Sleep Apnea (OSA).Journal of clinical medicine · 2023Article
- Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Article
- A Novel Clinical Tool to Detect Severe Obstructive Sleep Apnea.Nature and science of sleep · 2023Article
- The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study.International journal of clinical practice · 2023Observational
- Comparison of Clinical Features, Complete Blood Count Parameters, and Outcomes between Two Distinct Waves of COVID-19: A Monocentric Report from Italy.Healthcare (Basel, Switzerland) · 2022Article
- Impact of CPAP Therapy on New Inflammation Biomarkers.Journal of clinical medicine · 2022Article
- CPAP Influence on Readily Available Inflammatory Markers in OSA-A Pilot Study.International journal of molecular sciences · 2022Article
- Exploring red cell distribution width as a biomarker for treatment efficacy in home mechanical ventilation.BMC pulmonary medicine · 2022Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical detection of inflammatory markers is useful to assess the degree of nocturnal hypoxia and predict the presence of complications in obstructive sleep apnea syndrome (OSAS) patients. Nowadays, some researchers proposed that hematological parameters could be substituted for novel disease-specific biochemical markers (such as C-reactive protein) because they were comparatively cheap, simple and practical. But there was a contradiction whether the hematological parameters were positively correlated with the OSAS severity.
methodsMedical databases were searched included PubMed, Web of Science, Scopus, Cochrane Library, Clinical Trial, Embase and Google Scholar (up to March 29, 2018). We used weighted mean differences (WMDs) with 95% confidence intervals (CIs) from random-effects model.
resultsSeventeen studies were included in this meta-analysis and results were presented by different hematological parameters. Pooled analysis showed that OSAS was associated with a high level of WBC (white blood cell, 11 studies, 2,206 subjects, WMD: 0.58; 95% CI: 0.31 to 0.85; P<0.0001), NLR (neutrophil-to-lymphocyte ratio, 5 studies, 1416 subjects, WMD: 0.46; 95% CI: 0.13 to 0.80; P=0.007), MPV (mean platelet volume, 8 studies, 1,854 subjects, WMD: 0.63; 95% CI: 0.29 to 0.98; P=0.0004), PDW (platelet distribution width, 6 studies, 1,911 subjects, WMD: 0.76; 95% CI: 0.47 to 1.06; P<0.00001), PLR (platelet-to-lymphocyte ratio, 3 studies, 998 subjects, WMD: 21.76; 95% CI: 8.54 to 34.99; P=0.001), RDW (red cell distribution width, 5 studies, 1,701 subjects, WMD: 0.31; 95% CI: 0.11 to 0.51; P=0.002) and HCT (hematocrit, 3 studies, 662 subjects, WMD: 1.58; 95% CI: 0.52 to 2.64; P=0.003). But OSAS was associated with a low level of LYM (lymphocyte, 5 studies, 1,285 subjects, WMD: -0.27; 95% CI: -0.49 to -0.06; P=0.01). There was a gradual rising trend from mild OSAS to severe OSAS existed in all subgroups.
conclusionsHematological indices are comparatively Simple, Inexpensive and Practical Severity Markers of OSAS including WBC, LYM, NLR, MPV, PDW, PLR, RDW and HCT.
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