ArticleeLife2019
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- From neuropeptides to toxins: illuminating the origins of venom complexity in cone snails.Molecular biology and evolution · 2026Article
- Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata.Protein science : a publication of the Protein Society · 2026Article
- Multi-omics characterization of toxin expression and producing organs in the predatory gastropods Monoplex corrugatus and Stramonita haemastoma.BMC genomics · 2026Article
- Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026Review
- Venom Proteins of the FireflyToxins · 2025Article
- Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Regulation and function of insulin and insulin-like growth factor receptor signalling.Nature reviews. Molecular cell biology · 2025Review
- PeptideMiner-neuropeptide discovery across the animal kingdom.GigaScience · 2025Article
- Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules.Marine drugs · 2024Review
- Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin.Nature communications · 2024Article
- Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications.Journal, genetic engineering & biotechnology · 2024Article
- Synthesis and Hypoglycemic Effect of Insulin from the Venom of Sea AnemoneMarine drugs · 2024Article
- Size matters: the biochemical logic of ligand type in endocrine crosstalk.Life metabolism · 2024Article
- Review
- High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus.Acta crystallographica. Section F, Structural biology communications · 2023Article
- A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.PLoS biology · 2023Article
- Characterisation of Elevenin-Vc1 from the Venom ofMarine drugs · 2023Article
- Article
- Bioactive Peptides and Proteins from Centipede Venoms.Molecules (Basel, Switzerland) · 2022Review
- Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.Molecular biology and evolution · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Peter Ahorukomeye *Department of Biology, University of Utah School of Medicine, Salt Lake City, United States.
Maria M Disotuar *Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Joanna GajewiakDepartment of Biology, University of Utah School of Medicine, Salt Lake City, United States.
Santhosh KaranthMolecular Medicine Program, University of Utah, Salt Lake City, United States.
Maren WatkinsDepartment of Biology, University of Utah School of Medicine, Salt Lake City, United States.
Samuel D RobinsonDepartment of Biology, University of Utah School of Medicine, Salt Lake City, United States.
Paula Flórez SalcedoDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Nicholas A SmithLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
Brian J SmithLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
Amnon SchlegelDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID http://orcid.org/0000-0003-4060-2252
Briony E ForbesDepartment of Medical Biochemistry, Flinders University, Bedford Park, Australia.
Baldomero OliveraDepartment of Biology, University of Utah School of Medicine, Salt Lake City, United States.
Danny Hung-Chieh ChouDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Helena Safavi-HemamiDepartment of Biology, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-1984-2721
University of Utah · USLa Trobe University · AUFlinders University · AU
Funding
DEVELOPMENT OF CONCENTRATED, STABLE ULTRA FAST-ACTING INSULIN FORMULATIONR01DK120430 · NIDDK · UNIVERSITY OF UTAH · PI CHOU, DANNY HUNG-CHIEH · 2018 to 2021
$2.2MLife history-guided drug discovery from venomous marine snailsR01GM122869 · NIGMS · UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M, YANDELL, MARK DOUGLAS · 2018 to 2022
$1.5MJuvenile Diabetes Research Foundation United States of America 1-INO-2017-441-A-NNIDDK NIH HHS R01 DK120430NIGMS NIH HHS 1RO1GM122869NIGMS NIH HHS R01 GM122869
Abstract
The fish-hunting marine cone snail
Indexed as
AnimalsAntigens, CDConus SnailDisease Models, AnimalHumansHypoglycemiaInsulinMiceMolecular Dynamics SimulationMollusk VenomsPoisoningPoisonsReceptor, InsulinZebrafishAntigens, CDINSR protein, humanInsulinMollusk VenomsPoisonsReceptor, Insulinbiochemistrychemical biologycone snaildiabeteshypoglycemic shockinsulinprey capturevenom
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.