Evidence map›Paper›PMID 30755271›Full record

SynthesisSystematic reviews2019

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.

Chris Kite, Ian M Lahart, Islam Afzal, David R Broom, Harpal Randeva, Ioannis Kyrou, James E Brown

Registry-linked trialOpen access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06303219 (Comparative Effects of Traditional Moderate Intensity Training and High Intensity Interval Training on Anxiety, Fatigue and Quality of Life in Polycystic Ovarian Syndrome), which is not on this map. Cited by 59 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 7 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06303219 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparative Effects of Traditional Moderate Intensity Training and High Intensity Interval Training on Anxiety, Fatigue and Quality of Life in Polycystic Ovarian Syndrome

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled44ConditionsPolycystic Ovarian SyndromeArmsRADITIONAL MODERATE INTENSITY TRAINING, HIGH INTENSITY INTERVAL TRAINING
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 7 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
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  3. Efficacy of physical activity in polycystic ovary syndrome treatment.Current opinion in endocrinology, diabetes, and obesity · 2024
    Pooled it
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  13. [Physical activity in psychiatry: a practical guide for clinicians on patient communication about physical activity, exercise, and sport].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chris KiteSchool of Life and Health Sciences, Cell and Tissue Biomedical Research Group, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.ORCID 0000-0003-1342-274X
Ian M LahartFaculty of Education Health and Wellbeing, University of Wolverhampton, Walsall Campus, Gorway Road, Walsall, WS1 3BD, UK.ORCID 0000-0003-1079-2876
Islam AfzalAston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.ORCID 0000-0002-7961-7753
David R BroomAcademy of Sport and Physical Activity, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, S10 2BP, UK.ORCID 0000-0002-0305-937X
Harpal RandevaAston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.ORCID 0000-0001-9438-7506
Ioannis KyrouAston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.ORCID 0000-0002-6997-3439
James E BrownAston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK. J.E.P.Brown@aston.ac.uk.
Aston University · GBSheffield Hallam University · GBUniversity of Wolverhampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTypically, management of PCOS focuses on lifestyle changes (exercise and diet), aiming to alleviate symptoms, and lower the associated risk of type 2 diabetes and cardiovascular disease. Our objective was to analyse evidence on the effectiveness of exercise in the management of PCOS, when compared to (i) usual care, (ii) diet alone, and (iii) exercise combined with diet, and also exercise combined with diet, compared to (i) control or usual care and (ii) diet alone.

methodsRelevant databases were searched (June 2017) with no time limit for trial inclusion. Eligible trials employed a randomised or quasi-randomised design to measure the chronic effects of exercise, or exercise and diet in women with PCOS.

resultsSearches returned 2390 articles; of those, 27 papers from 18 trials were included. Results are presented as mean difference (MD) and 95% confidence intervals (95% CI). Compared with control, exercise had a statistical effect on change from baseline fasting insulin (MD - 2.44 μIU/mL, 95% CIs - 4.24 to - 0.64; very low-quality evidence), HOMA-IR (- 0.57, - 0.99 to - 0.14; very low-quality evidence), total cholesterol (- 5.88 mg/dL, - 9.92 to - 1.83; low-quality evidence), LDL cholesterol (- 7.39 mg/dL, - 9.83 to - 4.95; low-quality evidence), and triglycerides (- 4.78 mg/dL, - 7.52 to - 2.05; low-quality evidence). Exercise also improved VO

conclusionStatistically beneficial effects of exercise were found for a range of metabolic, anthropometric, and cardiorespiratory fitness-related outcomes. However, caution should be adopted when interpreting these findings since many outcomes present modest effects and wide CIs, and statistical effects in many analyses are sensitive to the addition/removal of individual trials. Future work should focus on rigorously designed, well-reported trials that make comparisons involving both exercise and diet. SYSTEMATIC REVIEW REGISTRATION: This systematic review was prospectively registered on the Prospero International Prospective Register of Systematic Reviews ( CRD42017062576 ).

Indexed as

DietAdultCombined Modality TherapyExercise TherapyFemaleHumansPolycystic Ovary SyndromeRandomized Controlled Trials as TopicYoung AdultCardiorespiratory fitnessCardiovascular riskDietExerciseInsulin resistancePhysical activityPolycystic ovary syndrome

Identifiers

PMID30755271
PMCPMC6371542
OpenAlexW2919006646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.