Evidence map›Paper›PMID 30763457›Full record

Trial reportMolecular nutrition & food research2019

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Steven K Malin, Emily L Kullman, Amanda R Scelsi, Jean-Philippe Godin, Alastair B Ross, John P Kirwan

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Steven K MalinDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Emily L KullmanDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Amanda R ScelsiDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Jean-Philippe GodinInstitute of Food Safety and Analytical Sciences, Nestlé Research Center, 1015, Lausanne, Switzerland.
Alastair B RossDepartment of Biology and Biological Engineering, Chalmers University of Technology, Chalmersplatsen 4, 412 96, Gothenburg, Sweden.
John P KirwanDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Cleveland Clinic Lerner College of Medicine · USChalmers University of Technology · SENestlé (Switzerland) · CH

Funding

Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
TRAINING IN METABOLISMT32DK007319 · CASE WESTERN RESERVE UNIVERSITY · 1986 to 2005
$2.1M
NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024989NIDDK NIH HHS T32 DK007319NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

introductionThe effect of whole-grain (WG) versus refined-grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function is unclear.

methodsIn a double-blind crossover randomized controlled trial, 13 prediabetic adults (37.2 ± 1.8 y, BMI: 33.6 ± 1.4 kg m

resultsBoth diets induce fat loss (≈2 kg). While neither diet impacts early phase GSIS, the WG diet increases total GSIS (iAUC of C-peptide

conclusionA WG-rich diet increases β-cell function independent of gut hormones in adults with prediabetes.

Indexed as

Insulin SecretionWhole GrainsAdultC-PeptideDiabetes Mellitus, Type 2DietDouble-Blind MethodFemaleGastrointestinal HormonesGlucoseHumansIncretinsInsulinMalePrediabetic StateC-PeptideGastrointestinal HormonesGlucoseIncretinsInsulinalkylresorcinolsglucose toleranceinsulinlow-glycemic dietobesity

Identifiers

PMID30763457
PMCPMC6559794
OpenAlexW2914773420

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.