Evidence map›Paper›PMID 30765332›Full record

ArticleCellular and molecular gastroenterology and hepatology2019

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.

Federica Laudisi, Davide Di Fusco, Vincenzo Dinallo, Carmine Stolfi, Antonio Di Grazia, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Claudia Alteri, Francesca Guerrieri and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Effects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review.International journal of environmental research and public health · 2022
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  13. Marked for Success: How RNA mCellular and molecular gastroenterology and hepatology · 2026
    Review
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  15. Impact ofMolecules (Basel, Switzerland) · 2025
    Article
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  20. Food Additives: Emerging Detrimental Roles on Gut Health.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Federica LaudisiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Davide Di FuscoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Vincenzo DinalloDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Carmine StolfiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Antonio Di GraziaDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Irene MarafiniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Alfredo ColantoniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Angela OrtenziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Claudia AlteriDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Francesca GuerrieriCenter for Life NanoScience at Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Maria MavilioDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Francesca Ceccherini-SilbersteinDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Massimo FedericiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Center for Atherosclerosis, Policlinico Tor Vergata, Rome, Italy.
Thomas Thornton MacDonaldBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom.
Ivan MonteleoneDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Giovanni MonteleoneDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: gi.monteleone@uniroma2.it.
University of Rome Tor Vergata · ITItalian Institute of Technology · ITQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsFood additives, such as emulsifiers, stabilizers, or bulking agents, are present in the Western diet and their consumption is increasing. However, little is known about their potential effects on intestinal homeostasis. In this study we examined the effect of some of these food additives on gut inflammation.

methodsMice were given drinking water containing maltodextrin (MDX), propylene glycol, or animal gelatin, and then challenged with dextran sulfate sodium or indomethacin. In parallel, mice fed a MDX-enriched diet were given the endoplasmic reticulum (ER) stress inhibitor tauroursodeoxycholic acid (TUDCA). Transcriptomic analysis, real-time polymerase chain reaction, mucin-2 expression, phosphorylated p38 mitogen-activated protein (MAP) kinase quantification, and H&E staining was performed on colonic tissues. Mucosa-associated microbiota composition was characterized by 16S ribosomal RNA sequencing. For the in vitro experiments, murine intestinal crypts and the human mucus-secreting HT29-methotrexate treated cell line were stimulated with MDX in the presence or absence of TUDCA or a p38 MAP kinase inhibitor.

resultsDiets enriched in MDX, but not propylene glycol or animal gelatin, exacerbated intestinal inflammation in both models. Analysis of the mechanisms underlying the detrimental effect of MDX showed up-regulation of inositol requiring protein 1β, a sensor of ER stress, in goblet cells, and a reduction of mucin-2 expression with no significant change in mucosa-associated microbiota. Stimulation of murine intestinal crypts and HT29-methotrexate treated cell line cells with MDX induced inositol requiring protein 1β via a p38 MAP kinase-dependent mechanism. Treatment of mice with TUDCA prevented mucin-2 depletion and attenuated colitis in MDX-fed mice.

conclusionsMDX increases ER stress in gut epithelial cells with the downstream effect of reducing mucus production and enhancing colitis susceptibility.

Indexed as

Disease ProgressionAnimalsCattleColitisDietEndoplasmic Reticulum StressEpithelial CellsFood AdditivesGastrointestinal MicrobiomeInflammationIntestinesMembrane ProteinsMice, Inbred BALB CMucusp38 Mitogen-Activated Protein KinasesPolysaccharidesErn2 protein, mouseFood AdditivesmaltodextrinMembrane Proteinsp38 Mitogen-Activated Protein KinasesPolysaccharidesProtein Serine-Threonine KinasesColitisIBDIntestinal EpitheliumUnfolded Protein Response

Identifiers

PMID30765332
PMCPMC6369223
OpenAlexW2889816593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.