ArticleScience (New York, N.Y.)2019
Parallel adaptation of rabbit populations to myxoma virus.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78citing papers in PubMed
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Who cites it
78 citing papers in PubMed.
- Variation in resistance and survival of the European bitterling fish across a gradient of Sinanodonta woodiana expansion.Oecologia · 2026Article
- Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Historical comparative genomics to track the evolution of fungal pathogens: a proof of concept.BMC genomics · 2026Article
- Enrichment and Reduction of Microsatellite Regions in the Myxoma Virus Genome Following Species Jump to the Iberian Hare (Transboundary and emerging diseases · 2026Article
- The First Confirmed Outbreak of Recombinant Myxomatosis Virus in the Brown Hare (Lepus europaeus P.) Population in Hungary.Transboundary and emerging diseases · 2026Article
- The impacts of European arrival on Australian dingoes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints.Molecular biology and evolution · 2025Article
- The Role of Myxoma Virus Immune Modulators and Host Range Factors in Pathogenesis and Species Leaping.Viruses · 2025Review
- SimOutbreakSelection: a simulation-based tool to optimise sampling design and analysis strategies for detecting epidemic-driven selection.Nature communications · 2025Article
- Genome-wide Parallelism Underlies Rapid Freshwater Adaptation Fueled by Standing Genetic Variation in a Wild Fish.Molecular biology and evolution · 2025Article
- Eradication efforts catalyze rapid evolution in an invasive predatory fish.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Conservation Evolutionary Biology: A Unified Framework Connecting the Past, Present, and Future of Biodiversity Conservation.Molecular biology and evolution · 2025Review
- Copy number variation contributes to parallel local adaptation in an invasive plant.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An interdisciplinary approach to improving conservation outcomes for parasites.Conservation biology : the journal of the Society for Conservation Biology · 2025Review
- Domestic European RabbitsTransboundary and emerging diseases · 2025Article
- Estimating the impact of sarcoptic mange epidemic on the population size of wild raccoon dogs (International journal for parasitology. Parasites and wildlife · 2024Article
- Screening great ape museum specimens for DNA viruses.Scientific reports · 2024Article
- Impact of putatively beneficial genomic loci on gene expression in little brown bats (Evolutionary applications · 2024Article
- Review
- Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Joel M AlvesDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. joel.alves@arch.ox.ac.uk miguel.carneiro@cibio.up.pt fmj1001@cam.ac.uk.ORCID 0000-0001-6138-9134
Miguel CarneiroCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal. joel.alves@arch.ox.ac.uk miguel.carneiro@cibio.up.pt fmj1001@cam.ac.uk.ORCID 0000-0001-9882-7775
Jade Y ChengDepartments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.
Ana Lemos de MatosThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.ORCID 0000-0003-3000-307X
Masmudur M RahmanThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
Liisa LoogPalaeogenomics and Bio-Archaeology Research Network Research Laboratory for Archaeology and History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, Oxford OX1 3QY, UK.ORCID 0000-0002-1770-101X
Paula F CamposCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.
Nathan WalesCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.ORCID 0000-0003-0359-8450
Anders ErikssonDepartment of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.ORCID 0000-0003-3436-3726
Andrea ManicaDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.ORCID 0000-0003-1895-450X
Tanja StriveHealth and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.ORCID 0000-0003-2971-8406
Stephen C GrahamDepartment of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.ORCID 0000-0003-4547-4034
Sandra AfonsoCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.ORCID 0000-0001-7212-991X
Diana J BellCentre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Laura BelmontThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
Jonathan P DayDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
Susan J FullerSchool of Earth, Environmental and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia.ORCID 0000-0003-4399-0166
Stéphane MarchandeauOffice National de la Chasse et de la Faune Sauvage, Nantes, France.
William J PalmerThe Genome Center and Department of Plant Sciences, University of California, Davis, CA 95616, USA.
Guillaume QueneyANTAGENE, Wildlife Genetics Laboratory, La Tour de Salvagny (Lyon), France.ORCID 0000-0002-6071-5169
Alison K SurridgeCentre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Filipe G VieiraCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.ORCID 0000-0002-8464-7770
Grant McFaddenThe Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy, Arizona State University, Tempe, AZ 85287-5401, USA.
Rasmus NielsenDepartments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-0513-6591
M Thomas P GilbertCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen 1350, Denmark.ORCID 0000-0002-5805-7195
Pedro J EstevesCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.
Nuno FerrandCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.ORCID 0000-0002-2408-4195
Francis M JigginsDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. joel.alves@arch.ox.ac.uk miguel.carneiro@cibio.up.pt fmj1001@cam.ac.uk.ORCID 0000-0001-7470-8157
Funding
Studies in Poxvirus Host Range Genes and TropismR01AI080607 · NIAID · UNIVERSITY OF FLORIDA · PI RAHMAN, MASMUDUR MOHAMMED · 2009 to 2025
$5.6MEuropean Research Council 281668NIAID NIH HHS R01 AI080607Wellcome Trust
Abstract
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.
Indexed as
Adaptation, BiologicalAllelesAnimalsAustraliaEvolution, MolecularFranceGene FrequencyGenetic VariationImmunity, InnateInterferon alpha-2Myxomatosis, InfectiousMyxoma virusPolymorphism, Single NucleotidePopulationRabbitsUnited KingdomInterferon alpha-2
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.